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CC BY-NC-ND 4.0 · Journal of Coloproctology 2022; 42(01): 020-024
DOI: 10.1055/s-0041-1736645
Original Article

Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria

Khaldoon Thanoon Al-Abachi 
1   Department of Medicine, University of Ninevah, Ninevah College of Medicine, Mosul, Iraq
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Abstract

Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria.

Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD.

Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation.

Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.

Keywords

irritable bowel syndrome - celiac disease - anti-tTG antibodies - duodenal biopsy

Ethical Approval

Ethical approval was granted by the Medical Ethics Committee of the Ninevah University.


Informed Consent

All participant agreed to sign an informed written consent form.


Note

Hospital-based study supported by Iraqi ministry of health. The patients were not charged, and no charge was received by the author.




Publication History

Received: 21 March 2021

Accepted: 15 June 2021

Article published online:
18 November 2021

© 2021. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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