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Thromb Haemost 1982; 47(02): 096-100
DOI: 10.1055/s-0038-1657137
Original Article
Schattauer GmbH Stuttgart

Activation of Human Coagulation Factor VIII by Activated Factor X, the Common Product of the Intrinsic and the Extrinsic Pathway of Blood Coagulation

K Mertens
The Haemostasis and Thrombosis Research Unit, Leiden University Hospital, Leiden, The Netherlands
,
R M Bertina
The Haemostasis and Thrombosis Research Unit, Leiden University Hospital, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 02 December 1981

Accepted 18 January 1982

Publication Date:
13 July 2018 (online)

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Summary

The intrinsic activation of human factor X has been studied in a system consisting of purified factors and in plasma. In both these systems factor Xa stimulated the activation of factor X by factor IXa plus factor VIII This is due to the activation of factor VIII by factor Xa. When this factor Xa is formed via the extrinsic pathway, the extrinsic factor X activator functions as a stimulator of the intrinsic factor X activator.

Key words

Factor VIII - Factor X - Intrinsic pathway - Extrinsic pathway
 

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