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Thromb Haemost 1967; 18(03/04): 726-735
DOI: 10.1055/s-0038-1655082
Originalarbeiten — Original Articles — Travaux Originaux
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Platelet Factor 3 and the Generalized Shwartzman Reaction[*]

G Müller-Berghaus M. D.
1   Department of Pathology, College of Physicians and Surgeons of Columbia University in the City of New York
,
D Goldfinger B. A.
1   Department of Pathology, College of Physicians and Surgeons of Columbia University in the City of New York
,
W Margaretten M. D.
1   Department of Pathology, College of Physicians and Surgeons of Columbia University in the City of New York
,
D. G McKay M. D.
1   Department of Pathology, College of Physicians and Surgeons of Columbia University in the City of New York
› Author Affiliations
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Publication History

Publication Date:
26 June 2018 (online)

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Summary

The mechanism of “provocation” of the generalized Shwartzman reaction was studied in rats and rabbits. Rats were “prepared” for the reaction by epsilon-aminocaproic acid or pregnancy, rabbits by Thorotrast or endotoxin. Infusions of different preparations of platelet factor 3 activity were not capable of “provoking” the Shwartzman reaction. Purified bovine platelet factor 3, rabbit brain tissue extracts in the form of “so-called” partial thromboplastin or a soya bean phospholipid preparation were used. The results suggest that in addition to the aggregation of platelets and the release of platelet factor 3 other actions of endotoxin are essential to the production of the generalized Shwartzman reaction.

* Aided by Grants HE-05666-06 and 5 T1 GM-865-05 from the National Institutes of Health, United States Public Health Service.


 

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