Kinder- und Jugendmedizin 2009; 09(06): 340-348
DOI: 10.1055/s-0038-1629057
Pneumologie
Schattauer GmbH

Wheezing beim Säugling und Kleinkind

Wann ist es Asthma?Wheezing in preschool childrenwhen is it asthma?
F. Prenzel
1   Universitätsklinik und Poliklinik für Kinder und Jugendliche Leipzig
› Author Affiliations
Further Information

Publication History

Eingereicht am: 03 June 2009

angenommen am: 17 June 2009

Publication Date:
25 January 2018 (online)

Zusammenfassung

Wheezing beim Säugling und Kleinkind ist ein ausgesprochen häufiges Phänomen. Eine Differenzierung von verschiedenen Phänotypen ist möglich und klinisch relevant, da sich sowohl Outcome als auch die Therapie unterscheiden. Bei der Mehrzahl der Kinder mit Wheezing verschwinden die Symptome bis zum 6. Lebensjahr. Erste Manifestationen eines Asthma bronchiale treten im selben Alter auf und führen bereits früh zu Lungenfunktionseinschränkungen. Eine Unterscheidung von einfachem Wheezing und Asthma ist daher von großer Bedeutung. In diesem Artikel werden unterschiedliche Charakteristika, Risikofaktoren für Asthma und einfache klinische Prädiktionsindizes dargestellt.

Summary

Wheezing in infants and toddlers is a very common phenomenon. Determination of the phenotype is possible and of clinical relevance due to the different outcome and management. In the majority of children the symptoms cease until the age of 6. First manifestations of persistent asthma occur in the same age associated with poor lung function. A distinction between common wheezing and asthma is therefore important. This article describes different characteristics, risk factors for asthma and simple clinical predictive indices.

 
  • Literatur

  • 1 Annesi-Maesano I, Moreau D, Strachan D. In utero and perinatal complications preceding asthma. Allergy 2001; 56 (06) 491-497.
  • 2 Arbes Jr SJ, Gergen PJ, Vaughn B, Zeldin DC. Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 2007; 120 (05) 1139-1145.
  • 3 Arshad SH, Kurukulaaratchy RJ, Fenn M, Matthews S. Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age. Chest 2005; 127 (02) 502-508.
  • 4 Bacharier LB, Phillips BR, Bloomberg GR. et al. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immunol 2007; 119 (03) 604-610.
  • 5 Bacharier LB, Boner A, Carlsen KH. et al. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 2008; 63 (01) 5-34.
  • 6 Ball TM, Castro-Rodriguez JA, Griffith KA. et al. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000; 343 (08) 538-543.
  • 7 Beasley R, Clayton T, Crane J. et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008; 372 9643 1039-1048.
  • 8 Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit Care Med 2006; 174 (02) 112-119.
  • 9 Bisgaard H, Zielen S, Garcia-Garcia ML. et al. Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma. Am J Respir Crit Care Med 2005; 171 (04) 315-322.
  • 10 Bisgaard H, Hermansen MN, Loland L. et al. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006; 354 (19) 1998-2005.
  • 11 Bisgaard H, Hermansen MN, Buchvald F. et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007; 357 (15) 1487-1495.
  • 12 Boehmer AL, Merkus PJ. Asthma therapy for children under 5 years of age. Curr Opin Pulm Med 2006; 12 (01) 34-41.
  • 13 Brand PL, Baraldi E, Bisgaard H. et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008; 32 (04) 1096-1110.
  • 14 Braun-Fahrlander C, Riedler J, Herz U. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347 (12) 869-877.
  • 15 Bush A. Practice imperfect – treatment for wheezing in preschoolers. N Engl J Med 2009; 360 (04) 409-410.
  • 16 Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162 4 Pt 4 1403-1406.
  • 17 Castro-Rodriguez JA, Garcia-Marcos L, Alfonseda Rojas JD. et al. Mediterranean diet as a protective factor for wheezing in preschool children. J Pediatr 2008; 152 (06) 823-828.
  • 18 Chan EY, Dundas I, Bridge PD. et al. Skin-prick testing as a diagnostic aid for childhood asthma. Pediatr Pulmonol 2005; 39 (06) 558-562.
  • 19 Davies G, Paton JY, Beaton SJ. et al. Children admitted with acute wheeze/asthma during November 1998–2005: a national UK audit. Arch Dis Child 2008; 93 (11) 952-958.
  • 20 Devulapalli CS, Carlsen KC, Haland G. et al. Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age. Thorax 2008; 63 (01) 8-13.
  • 21 Ducharme FM, Lemire C, Noya FJ. et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med 2009; 360 (04) 339-353.
  • 22 Dundas I, Chan EY, Bridge PD, McKenzie SA. Diagnostic accuracy of bronchodilator responsiveness in wheezy children. Thorax 2005; 60 (01) 13-16.
  • 23 Dunstan JA, Mori TA, Barden A. et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003; 112 (06) 1178-1184.
  • 24 Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2001; 163 (02) 429-436.
  • 25 Global Initiative for Asthma (GINA).. From the Global Strategy for the Diagnosis and Management of Asthma. Available from: http://www.ginasthma.org. 2008
  • 26 Global Initiative for Asthma (GINA). 2009. From the Global Strategy for the Diagnosis and Management of Asthma in Children 5 Years and Younger. Available from: http://www.ginasthma.org. 2009
  • 27 Goksor E, Gustafsson PM, Alm B. et al. Reduced airway function in early adulthood among subjects with wheezing disorder before two years of age. Pediatr Pulmonol 2008; 43 (04) 396-403.
  • 28 Greer FR, Sicherer SH, Burks AW. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 2008; 121 (01) 183-191.
  • 29 Guilbert TW, Morgan WJ, Zeiger RS. et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004; 114 (06) 1282-1287.
  • 30 Guilbert TW, Morgan WJ, Zeiger RS. et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006; 354 (19) 1985-1997.
  • 31 Henderson J, Hilliard TN, Sherriff A. et al. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr Allergy Immunol 2005; 16 (05) 386-392.
  • 32 Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res 2003; 4: 14.
  • 33 Holt PG, Upham JW, Sly PD. Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies. J Allergy Clin Immunol 2005; 116 (01) 16-24.
  • 34 Illi S, von Mutius E, Lau S. et al. The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol 2001; 108 (05) 709-714.
  • 35 Illi S, von Mutius E, Lau S. et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004; 113 (05) 925-931.
  • 36 Illi S, von Mutius E, Lau S. et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006; 368 9537 763-770.
  • 37 Kaditis AG, Winnie G, Syrogiannopoulos GA. Anti-inflammatory pharmacotherapy for wheezing in preschool children. Pediatr Pulmonol 2007; 42 (05) 407-420.
  • 38 Krawiec ME, Westcott JY, Chu HW. et al. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med 2001; 163 (06) 1338-1343.
  • 39 Kulig M, Bergmann R, Tacke U. et al. Long-lasting sensitization to food during the first two years precedes allergic airway disease. The MAS Study Group, Germany. Pediatr Allergy Immunol 1998; 9 (02) 61-67.
  • 40 Kusel MM, de Klerk NH, Kebadze T. et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007; 119 (05) 1105-1110.
  • 41 Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic?. J Allergy Clin Immunol 2007; 120 (05) 1031-1035.
  • 42 Marguet C, Jouen-Boedes F, Dean TP, Warner JO. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med 1999; 159 5 Pt 5 1533-1540.
  • 43 Martinez FD, Wright AL, Taussig LM. et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332 (03) 133-138.
  • 44 Matricardi PM, Illi S, Gruber C. et al. Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence. Eur Respir J 2008; 32 (03) 585-592.
  • 45 Moffatt MF, Kabesch M, Liang L. et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448 7152 470-473.
  • 46 Morgan WJ, Crain EF, Gruchalla RS. et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 2004; 351 (11) 1068-1080.
  • 47 Morgan WJ, Stern DA, Sherrill DL. et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med 2005; 172 (10) 1253-1258.
  • 48 Moshammer H, Hoek G, Luttmann-Gibson H. et al. Parental smoking and lung function in children: an international study. Am J Respir Crit Care Med 2006; 173 (11) 1255-1263.
  • 49 Nickel R, Kulig M, Forster J. et al. Sensitization to hen’s egg at the age of twelve months is predictive for allergic sensitization to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997; 99 (05) 613-617.
  • 50 Panickar J, Lakhanpaul M, Lambert PC. et al. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med 2009; 360 (04) 329-338.
  • 51 Peat JK, Mellis CM. Early predictors of asthma. Curr Opin Allergy Clin Immunol 2002; 2 (03) 167-173.
  • 52 Pekkanen J, Xu B, Jarvelin MR. Gestational age and occurrence of atopy at age 31 – a prospective birth cohort study in Finland. Clin Exp Allergy 2001; 31 (01) 95-102.
  • 53 Pizzichini MM, Popov TA, Efthimiadis A. et al. Spontaneous and induced sputum to measure indices of airway inflammation in asthma. Am J Respir Crit Care Med 1996; 154 4 Pt 4 866-869.
  • 54 Polte T, Hennig C, Hansen G. Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. J Allergy Clin Immunol 2008; 122 (05) 1022-1030.
  • 55 Riedler J, Braun-Fahrlander C, Eder W. et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358 9288 1129-1133.
  • 56 Rusconi F, Patria MF, Cislaghi GU. et al. Total serum IgE and outcome in infants with recurrent wheezing. Arch Dis Child 2001; 85 (01) 23-25.
  • 57 Saito J, Harris WT, Gelfond J. et al. Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. Pediatr Pulmonol 2006; 41 (08) 709-719.
  • 58 Sears MR, Greene JM, Willan AR. et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349 (15) 1414-1422.
  • 59 Sigurs N, Gustafsson PM, Bjarnason R. et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 2005; 171 (02) 137-141.
  • 60 Sly PD, Boner AL, Bjorksten B. et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet 2008; 372 9643 1100-1106.
  • 61 Stein RT, Holberg CJ, Morgan WJ. et al. Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing pheno-types in childhood. Thorax 1997; 52 (11) 946-952.
  • 62 Stern DA, Morgan WJ, Halonen M. et al. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 2008; 372 9643 1058-1064.
  • 63 Taussig LM, Wright AL, Holberg CJ. et al. Tucson Children’s Respiratory Study: 1980 to present. J Allergy Clin Immunol 2003; 111 (04) 661-675.
  • 64 Wever-Hess J, Hermans J, Kouwenberg JM. et al. Hospital admissions and readmissions for asthma in the age group 0–4 years. Pediatr Pulmonol 2001; 31 (01) 30-36.
  • 65 Yazdanbakhsh M, Kremsner PG, van Ree R. Allergy, parasites, and the hygiene hypothesis. Science 2002; 296 5567 490-494.