Semin Respir Crit Care Med 2017; 38(06): 840-852
DOI: 10.1055/s-0037-1608770
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Imaging in Neurocritical Care Practice

Craig Williamson
1   Department of Neurosurgery and Neurology, University of Michigan, Ann Arbor, Michigan
,
Larry Morgan
2   Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan
,
Joshua P. Klein
3   Division of Hospital Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2017 (online)

Abstract

The use of neuroimaging in conjunction with serial neurological examinations is a core component of modern neurocritical care practice. Although there is a growing role for other neuromonitoring techniques, the ability to quickly and accurately interpret images in the context of a patient's clinical status arguably remains the indispensable skill for neurocritical care practitioners. Due to its rapid acquisition time and excellent ability to detect intracerebral hemorrhage (ICH), cerebral edema, and signs of elevated intracranial pressure, computed tomography (CT) remains the most useful neuroimaging technique for intensive care unit (ICU) patients. An emergent head CT is obtained to inform most time-sensitive decisions that arise in the neurological ICU (NICU). CT features also figure prominently in prognostic scores for common NICU conditions such as traumatic brain injury (TBI), ICH, and subarachnoid hemorrhage (SAH). Among patients who are sufficiently stable to leave the ICU and lie flat for an extended period, magnetic resonance imaging provides much more detailed, high-contrast images which can aid in the detection of ischemia, diffuse axonal injury, and neuroprognostication. Though primarily used in neurocritical care research, nuclear medicine imaging techniques have some clinical applications, particularly in ancillary testing for brain death. Finally, as in the field of critical care as a whole, formal and point-of-care ultrasound studies are increasingly utilized in the NICU, and are an important tool in the neurointensivist's armamentarium. We review here the common applications of imaging in the neurocritical care setting. As ICU patients are frequently unstable and their risk of clinical decompensation increases substantially during transport away from the ICU, guidelines and recommendations for maximizing patient safety during transport to radiology studies are also explored.

 
  • References

  • 1 Bodanapally UK, Sours C, Zhuo J, Shanmuganathan K. Imaging of traumatic brain injury. Radiol Clin North Am 2015; 53 (04) 695-715 , viii
  • 2 Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT. ; Workshop Scientific Team and Advisory Panel Members. Classification of traumatic brain injury for targeted therapies. J Neurotrauma 2008; 25 (07) 719-738
  • 3 Edlow JA, Caplan LR. Avoiding pitfalls in the diagnosis of subarachnoid hemorrhage. N Engl J Med 2000; 342 (01) 29-36
  • 4 Peterson EC, Chesnut RM. Talk and die revisited: bifrontal contusions and late deterioration. J Trauma 2011; 71 (06) 1588-1592
  • 5 Alahmadi H, Vachhrajani S, Cusimano MD. The natural history of brain contusion: an analysis of radiological and clinical progression. J Neurosurg 2010; 112 (05) 1139-1145
  • 6 Kurland D, Hong C, Aarabi B, Gerzanich V, Simard JM. Hemorrhagic progression of a contusion after traumatic brain injury: a review. J Neurotrauma 2012; 29 (01) 19-31
  • 7 Young LA, Rule GT, Bocchieri RT, Burns JM. Biophysical mechanisms of traumatic brain injuries. Semin Neurol 2015; 35 (01) 5-11
  • 8 Brain Trauma Foundation; American Association of Neurological Surgeons and Congress of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007; 24 (Suppl. 01) S1-S106
  • 9 Chesnut RM, Temkin N, Carney N. , et al; Global Neurotrauma Research Group. A trial of intracranial-pressure monitoring in traumatic brain injury. N Engl J Med 2012; 367 (26) 2471-2481
  • 10 Eisenberg HM, Gary Jr HE, Aldrich EF. , et al. Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 1990; 73 (05) 688-698
  • 11 Miller MT, Pasquale M, Kurek S. , et al. Initial head computed tomographic scan characteristics have a linear relationship with initial intracranial pressure after trauma. J Trauma 2004; 56 (05) 967-972 , discussion 972–973
  • 12 Mizutani T, Manaka S, Tsutsumi H. Estimation of intracranial pressure using computed tomography scan findings in patients with severe head injury. Surg Neurol 1990; 33 (03) 178-184
  • 13 Chen W, Cockrell CH, Ward K, Najarian K. Predictability of intracranial pressure level in traumatic brain injury: features extraction, statistical analysis and machine learning-based evaluation. Int J Data Min Bioinform 2013; 8 (04) 480-494
  • 14 Chen W, Belle A, Cockrell C, Ward KR, Najarian K. Automated midline shift and intracranial pressure estimation based on brain CT images. J Vis Exp 2013; 74 (74) 3871
  • 15 Marshall LF, Marshall SB, Klauber MR. , et al. A new classification of head injury based on computerized tomography. J Neurosurg 1991; 75 (01) S14-S20
  • 16 Maas AI, Hukkelhoven CW, Marshall LF, Steyerberg EW. Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors. Neurosurgery 2005; 57 (06) 1173-1182 , discussion 1173–1182
  • 17 Gentry LR. Imaging of closed head injury. Radiology 1994; 191 (01) 1-17
  • 18 Gentry LR, Godersky JC, Thompson B. MR imaging of head trauma: review of the distribution and radiopathologic features of traumatic lesions. AJR Am J Roentgenol 1988; 150 (03) 663-672
  • 19 Huisman TA, Sorensen AG, Hergan K, Gonzalez RG, Schaefer PW. Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury. J Comput Assist Tomogr 2003; 27 (01) 5-11
  • 20 Parizel PM, Ozsarlak O, Van Goethem JW. , et al. Imaging findings in diffuse axonal injury after closed head trauma. Eur Radiol 1998; 8 (06) 960-965
  • 21 Wang JY, Bakhadirov K, Devous Sr MD. , et al. Diffusion tensor tractography of traumatic diffuse axonal injury. Arch Neurol 2008; 65 (05) 619-626
  • 22 Huisman TA, Schwamm LH, Schaefer PW. , et al. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol 2004; 25 (03) 370-376
  • 23 Ware JB, Hart T, Whyte J, Rabinowitz A, Detre JA, Kim J. Inter-subject variability of axonal injury in diffuse traumatic brain injury. J Neurotrauma 2017; 34 (14) 2243-2253
  • 24 Dubosh NM, Bellolio MF, Rabinstein AA, Edlow JA. Sensitivity of early brain computed tomography to exclude aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Stroke 2016; 47 (03) 750-755
  • 25 Cortnum S, Sørensen P, Jørgensen J. Determining the sensitivity of computed tomography scanning in early detection of subarachnoid hemorrhage. Neurosurgery 2010; 66 (05) 900-902 , discussion 903
  • 26 Connolly Jr ES, Rabinstein AA, Carhuapoma JR. , et al; American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2012; 43 (06) 1711-1737
  • 27 Shimoda M, Hoshikawa K, Shiramizu H, Oda S, Matsumae M. Problems with diagnosis by fluid-attenuated inversion recovery magnetic resonance imaging in patients with acute aneurysmal subarachnoid hemorrhage. Neurol Med Chir (Tokyo) 2010; 50 (07) 530-537
  • 28 Fiebach JB, Schellinger PD, Geletneky K. , et al. MRI in acute subarachnoid haemorrhage; findings with a standardised stroke protocol. Neuroradiology 2004; 46 (01) 44-48
  • 29 van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. Lancet 2007; 369 (9558): 306-318
  • 30 Adams Jr HP, Kassell NF, Torner JC, Sahs AL. CT and clinical correlations in recent aneurysmal subarachnoid hemorrhage: a preliminary report of the Cooperative Aneurysm Study. Neurology 1983; 33 (08) 981-988
  • 31 Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 1980; 6 (01) 1-9
  • 32 Claassen J, Bernardini GL, Kreiter K. , et al. Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited. Stroke 2001; 32 (09) 2012-2020
  • 33 Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke 1990; 21 (08) 1156-1161
  • 34 Dupont SA, Wijdicks EF, Manno EM, Lanzino G, Rabinstein AA. Prediction of angiographic vasospasm after aneurysmal subarachnoid hemorrhage: value of the Hijdra sum scoring system. Neurocrit Care 2009; 11 (02) 172-176
  • 35 Brott T, Broderick J, Kothari R. , et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997; 28 (01) 1-5
  • 36 Dowlatshahi D, Demchuk AM, Flaherty ML, Ali M, Lyden PL, Smith EE. ; VISTA Collaboration. Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes. Neurology 2011; 76 (14) 1238-1244
  • 37 Hemphill III JC, Greenberg SM, Anderson CS. , et al; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2015; 46 (07) 2032-2060
  • 38 Smith EE, Rosand J, Greenberg SM. Hemorrhagic stroke. Neuroimaging Clin N Am 2005; 15 (02) 259-272 , ix
  • 39 Fewell ME, Thompson BG, Hoff JT. Spontaneous intracerebral hemorrhage: a review. Neurosurg Focus 2003; 15: 1-16
  • 40 Gandhi D, Chen J, Pearl M, Huang J, Gemmete JJ, Kathuria S. Intracranial dural arteriovenous fistulas: classification, imaging findings, and treatment. AJNR Am J Neuroradiol 2012; 33 (06) 1007-1013
  • 41 Kondziolka D, Bernstein M, Resch L. , et al. Significance of hemorrhage into brain tumors: clinicopathological study. J Neurosurg 1987; 67 (06) 852-857
  • 42 Iwama T, Ohkuma A, Miwa Y. , et al. Brain tumors manifesting as intracranial hemorrhage. Neurol Med Chir (Tokyo) 1992; 32 (03) 130-135
  • 43 Little JR, Dial B, Bélanger G, Carpenter S. Brain hemorrhage from intracranial tumor. Stroke 1979; 10 (03) 283-288
  • 44 Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001; 56 (04) 537-539
  • 45 Cloft HJ, Joseph GJ, Dion JE. Risk of cerebral angiography in patients with subarachnoid hemorrhage, cerebral aneurysm, and arteriovenous malformation: a meta-analysis. Stroke 1999; 30 (02) 317-320
  • 46 Westerlaan HE, van Dijk JM, Jansen-van der Weide MC. , et al. Intracranial aneurysms in patients with subarachnoid hemorrhage: CT angiography as a primary examination tool for diagnosis--systematic review and meta-analysis. Radiology 2011; 258 (01) 134-145
  • 47 Philipp LR, McCracken DJ, McCracken CE. , et al. Comparison Between CTA and Digital Subtraction Angiography in the Diagnosis of Ruptured Aneurysms. Neurosurgery 2017; 80 (05) 769-777
  • 48 Gross BA, Frerichs KU, Du R. Sensitivity of CT angiography, T2-weighted MRI, and magnetic resonance angiography in detecting cerebral arteriovenous malformations and associated aneurysms. J Clin Neurosci 2012; 19 (08) 1093-1095
  • 49 Wada R, Aviv RI, Fox AJ. , et al. CT angiography “spot sign” predicts hematoma expansion in acute intracerebral hemorrhage. Stroke 2007; 38 (04) 1257-1262
  • 50 Frontera JA, Fernandez A, Schmidt JM. , et al. Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?. Stroke 2009; 40 (06) 1963-1968
  • 51 Nolan CP, Macdonald RL. Can angiographic vasospasm be used as a surrogate marker in evaluating therapeutic interventions for cerebral vasospasm?. Neurosurg Focus 2006; 21 (03) E1-E8
  • 52 Greenberg ED, Gold R, Reichman M. , et al. Diagnostic accuracy of CT angiography and CT perfusion for cerebral vasospasm: a meta-analysis. AJNR Am J Neuroradiol 2010; 31 (10) 1853-1860
  • 53 Powers WJ, Clarke WR, Grubb Jr RL, Videen TO, Adams Jr HP, Derdeyn CP. ; COSS Investigators. Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial. JAMA 2011; 306 (18) 1983-1992
  • 54 Conrad GR, Sinha P. Scintigraphy as a confirmatory test of brain death. Semin Nucl Med 2003; 33 (04) 312-323
  • 55 Harrigan MR, Leonardo J, Gibbons KJ, Guterman LR, Hopkins LN. CT perfusion cerebral blood flow imaging in neurological critical care. Neurocrit Care 2005; 2 (03) 352-366
  • 56 Saver JL, Goyal M, Bonafe A. , et al; SWIFT PRIME Investigators. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015; 372 (24) 2285-2295
  • 57 Campbell BC, Mitchell PJ, Kleinig TJ. , et al; EXTEND-IA Investigators. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 2015; 372 (11) 1009-1018
  • 58 Lansberg MG, Christensen S, Kemp S. , et al; CT Perfusion to Predict Response to Recanalization in Ischemic Stroke Project (CRISP) Investigators. Computed Tomographic Perfusion to Predict Response to Recanalization in Ischemic Stroke. Ann Neurol 2017; 81 (06) 849-856
  • 59 Sanelli PC, Ugorec I, Johnson CE. , et al. Using quantitative CT perfusion for evaluation of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol 2011; 32 (11) 2047-2053
  • 60 Dankbaar JW, de Rooij NK, Velthuis BK, Frijns CJ, Rinkel GJ, van der Schaaf IC. Diagnosing delayed cerebral ischemia with different CT modalities in patients with subarachnoid hemorrhage with clinical deterioration. Stroke 2009; 40 (11) 3493-3498
  • 61 Wintermark M, Ko NU, Smith WS, Liu S, Higashida RT, Dillon WP. Vasospasm after subarachnoid hemorrhage: utility of perfusion CT and CT angiography on diagnosis and management. AJNR Am J Neuroradiol 2006; 27 (01) 26-34
  • 62 Aralasmak A, Akyuz M, Ozkaynak C, Sindel T, Tuncer R. CT angiography and perfusion imaging in patients with subarachnoid hemorrhage: correlation of vasospasm to perfusion abnormality. Neuroradiology 2009; 51 (02) 85-93
  • 63 Sanelli PC, Pandya A, Segal AZ. , et al. Cost-effectiveness of CT angiography and perfusion imaging for delayed cerebral ischemia and vasospasm in aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol 2014; 35 (09) 1714-1720
  • 64 Lee MH, Smyser CD, Shimony JS. Resting-state fMRI: a review of methods and clinical applications. AJNR Am J Neuroradiol 2013; 34 (10) 1866-1872
  • 65 Monti MM, Vanhaudenhuyse A, Coleman MR. , et al. Willful modulation of brain activity in disorders of consciousness. N Engl J Med 2010; 362 (07) 579-589
  • 66 American College of Radiology (ACR); Society for Pediatric Radiology (SPR); Society of Radiologists in Ultrasound (SRU). AIUM practice guideline for the performance of a transcranial Doppler ultrasound examination for adults and children. J Ultrasound Med 2012; 31 (09) 1489-1500
  • 67 Marshall SA, Nyquist P, Ziai WC. The role of transcranial Doppler ultrasonography in the diagnosis and management of vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurg Clin N Am 2010; 21 (02) 291-303
  • 68 Gonzalez NR, Boscardin WJ, Glenn T, Vinuela F, Martin NA. Vasospasm probability index: a combination of transcranial Doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurg 2007; 107 (06) 1101-1112
  • 69 Sliwka U, Job F-P, Wissuwa D. , et al. Occurrence of transcranial Doppler high-intensity transient signals in patients with potential cardiac sources of embolism. A prospective study. Stroke 1995; 26 (11) 2067-2070
  • 70 Droste DW, Reisener M, Kemény V. , et al. Contrast transcranial Doppler ultrasound in the detection of right-to-left shunts. Reproducibility, comparison of 2 agents, and distribution of microemboli. Stroke 1999; 30 (05) 1014-1018
  • 71 Nemec JJ, Marwick TH, Lorig RJ. , et al. Comparison of transcranial Doppler ultrasound and transesophageal contrast echocardiography in the detection of interatrial right-to-left shunts. Am J Cardiol 1991; 68 (15) 1498-1502
  • 72 Komar M, Olszowska M, Przewłocki T. , et al. Transcranial Doppler ultrasonography should it be the first choice for persistent foramen ovale screening?. Cardiovasc Ultrasound 2014; 12: 16
  • 73 Brandt T, Knauth M, Wildermuth S. , et al. CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia. Stroke 1999; 30 (03) 606-612
  • 74 Kermer P, Wellmer A, Crome O, Mohr A, Knauth M, Bähr M. Transcranial color-coded duplex sonography in suspected acute basilar artery occlusion. Ultrasound Med Biol 2006; 32 (03) 315-320
  • 75 Roshanzamir S, Showkathali R. Takotsubo cardiomyopathy a short review. Curr Cardiol Rev 2013; 9 (03) 191-196
  • 76 Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 2008; 155 (03) 408-417
  • 77 Lichtenstein D, Mézière G, Biderman P, Gepner A, Barré O. The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome. Am J Respir Crit Care Med 1997; 156 (05) 1640-1646
  • 78 Williamson CA, Co I, Pandey AS, Gregory Thompson B, Rajajee V. Accuracy of daily lung ultrasound for the detection of pulmonary edema following subarachnoid hemorrhage. Neurocrit Care 2016; 24 (02) 189-196
  • 79 Davison DL, Terek M, Chawla LS. Neurogenic pulmonary edema. Crit Care 2012; 16 (02) 212
  • 80 Schwebel C, Clec'h C, Magne S. , et al; OUTCOMEREA Study Group. Safety of intrahospital transport in ventilated critically ill patients: a multicenter cohort study*. Crit Care Med 2013; 41 (08) 1919-1928
  • 81 Ferdinande P. ; Working Group on Neurosurgical Intensive Care of the European Society of Intensive Care Medicine. Recommendations for intra-hospital transport of the severely head injured patient. Intensive Care Med 1999; 25 (12) 1441-1443
  • 82 Warren J, Fromm Jr RE, Orr RA, Rotello LC, Horst HM. ; American College of Critical Care Medicine. Guidelines for the inter- and intrahospital transport of critically ill patients. Crit Care Med 2004; 32 (01) 256-262
  • 83 Brunsveld-Reinders AH, Arbous MS, Kuiper SG, de Jonge E. A comprehensive method to develop a checklist to increase safety of intra-hospital transport of critically ill patients. Crit Care 2015; 19: 214
  • 84 Gunnarsson T, Theodorsson A, Karlsson P. , et al. Mobile computerized tomography scanning in the neurosurgery intensive care unit: increase in patient safety and reduction of staff workload. J Neurosurg 2000; 93 (03) 432-436
  • 85 Peace K, Maloney-Wilensky E, Frangos S. , et al. Portable head CT scan and its effect on intracranial pressure, cerebral perfusion pressure, and brain oxygen. J Neurosurg 2011; 114 (05) 1479-1484