Gesundheitswesen 2017; 79(08/09): 656-804
DOI: 10.1055/s-0037-1605854
Vorträge
Georg Thieme Verlag KG Stuttgart · New York

A retrospective analysis of paediatric inpatient data on antibiotic use in a teaching hospital in The Gambia

PS Chaw
1   PhD Programme „Epidemiology“ Braunschweig-Hannover, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
2   ESME – Epidemiological and Statistical Methods Research Group, Department of Epidemiology, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
3   Institute for Medical Epidemiology, Biometry, and Informatics (IMEBI), Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle (Saale)
,
KM Schlinkmann
1   PhD Programme „Epidemiology“ Braunschweig-Hannover, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
2   ESME – Epidemiological and Statistical Methods Research Group, Department of Epidemiology, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
,
H Raupach-Rosin
2   ESME – Epidemiological and Statistical Methods Research Group, Department of Epidemiology, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
,
A Karch
1   PhD Programme „Epidemiology“ Braunschweig-Hannover, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
2   ESME – Epidemiological and Statistical Methods Research Group, Department of Epidemiology, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
,
J Huebner
4   Dr. Von Hauner Children's Hospital, Ludwig Maximilian University Munich, Division of Pediatric Infectious Diseases, Munich
,
R Mikolajczyk
1   PhD Programme „Epidemiology“ Braunschweig-Hannover, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
2   ESME – Epidemiological and Statistical Methods Research Group, Department of Epidemiology, Helmholtz Centre for Infection Research, Epidemiology, Braunschweig
5   Hannover Medical School, Hannover
3   Institute for Medical Epidemiology, Biometry, and Informatics (IMEBI), Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle (Saale)
› Author Affiliations
Further Information

Publication History

Publication Date:
01 September 2017 (online)

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Background:

Antibiotics are important in treating bacterial infections but resistance is a major problem and less well documented in developing countries. The aim of the study was to analyse antibiotic use in hospitalized children with respect to patients' diagnoses and microbiological testing.

Methods:

We conducted a retrospective analysis of paediatric inpatient data at The Edward Francis Small Teaching Hospital in Banjul, The Gambia. We used an access database to extract data from the admission folders of all patients (aged > 28 days to ≤15 years) admitted in 2015 (January-December), who received at least one antibiotic for 24 hours. We excluded records of patients who were discharged against medical advice and admission folders with inappropriate dating or loss of documents containing antibiotic and/or diagnosis details.

Results:

Over half of the admitted patients received at least one antibiotic during hospital stay (497/917). Ampicillin was the most commonly used antibiotic (38% (188/497)), and resistance against ampicillin was most common among the resistant isolates (23% (9/39)). Pneumonia was the most common diagnosis on admission among these patients that received antibiotics (20% (100/497)). Of the total test specimens on admission (50% (248/497)), 67% (165/248) had no documented results, 24% (59/248) showed no growth, the remaining 10% (24/248) were positive. Among these, Klebsiella sp. were the most often isolated organism (33% (8/24)) and had the highest reported antibiotic resistance (49% (19/39)).

Conclusion:

There was a significant proportion of the patients who received antibiotics, with deficiencies in microbiological tests. Antibiotic resistance was highest for the most commonly used antibiotics. More specific studies on the resistance profile of the commonly isolated organisms would be useful epidemiologically and in helping to decide on rational antibiotic use.

KEY WORDS: Paediatrics, antibiotics, microbiology tests, resistance.