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DOI: 10.1055/s-0034-1383947
Image-Guided Stereotactic Biopsy for the Brain Lesions: 2,315 Case Reports
Objectives: To summarize the significance of image-guided stereotactic biopsy (STB) in the diagnosis of nervous system diseases by presenting the 24-year experience in STB. Methods: A total of 2,315 cases of brain lesions underwent image-guided STB from December, 1987 to December, 2011 in our department were retrospectively studied. CT-guided STB was performed in 1,171 cases, MR-guided STB in 1,108 cases and PET-CT-guided STB in 36 cases. Result: Neoplasm was diagnosed in 1,917 cases and nonneoplasm was found in 338 cases. The positive diagnosis rate of biopsy was 97.41%. Transient neurologic deficits caused by small hematoma (< 10 mL) or edema were found in 39 cases, large hematoma that need neurosurgical treatment in 18 cases. Eight (0.35%) cases died from biopsy-related massive hemorrhage. There were no severe intracranial infection cases. In 191 cases underwent 1H-MRS-guided STB, the positive diagnosis rate was 98%. The metabolic and biochemical environment of area of interest (AOI) could be quantitatively analyzed by evaluating proton magnetic resonance spectroscopy. The target and range of biopsy could be decided easily and the accurate rate of diagnosis could be improved remarkably. Conclusion: The STB employing advanced image-guided technique represents a safe, reliable, and minimally invasive method for pathological diagnosis of intracranial lesions. Moreover, the developments of biochemical imaging such as MRS and PET-CT images give new concept to STB.