Planta Med 2014; 80 - PD36
DOI: 10.1055/s-0034-1382457

Studies on the constituents of Chloranthus japonicus sieb.

SY Kim 1, N Tanaka 2, Y Kashiwada 2, Y Takaishi 2, J Kobayashi 3, M Kojoma 1
  • 1Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido; Tobetsu, Hokkaido 061 – 0293, Japan
  • 2Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770 – 8505, Japan
  • 3Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 – 0812, Japan

We have been studying secondary metabolites of plants growing in Hokkaido, Japan, in order to search for new natural templates of therapeutic agents. As part of this research program, we have investigated for constituents of plants belonging to the genus Chloranthus (Chloranthaceae). This genus contains about 10 species, which distributed in the tropical zone of Asia and in the temperate zone of East Asia. Several lindenane-sesquiterpene dimers with complex structures and unique biological activities have been isolated from Chloranthus plants.

The extract of Chloranthus japonicus was separated by repeated column chromatography to give three new compounds. Their structures were determined by analyses of the spectroscopic data. The isolation and structure elucidation of these compounds will be presented.