Thorac Cardiovasc Surg 2014; 62 - SC159
DOI: 10.1055/s-0034-1367420

Effect of recombinant-BNP-infusions on renal function following total artificial heart-implantation

S. Spiliopoulos 1, M.R. Serrano 1, D. Guersoy 1, G. Dogan 1, R. Koerfer 1, G. Tenderich 1
  • 1Klinik für Herz- und Gefässchirurgie Duisburg, Abteilung für die chirurgische Therapie der terminalen Herzinsuffizienz und Kunstherzversorgung, Duisburg, Germany

Objectives: Excision of the native ventricles results into depletion of BNP and compromise of renal function following Total Artificial Heart (TAH) implantation. BNP substitution could ameliorate this effect and reduce the need for haemodialysis.

Methods: We retrospectively reviewed 22 TAH-implantations performed from 2011 to 2013 in our institution with regard to renal function. 11 patients received continuous recombinant BNP infusions (1,5 g/250 ml NaCl) directly after the excision of the native ventricles. Depending on urine output BNP-therapy was gradually withdrawn. We focused on the need for haemodialysis, urine output and GFR.

Results: In patients treated with recombinant BNP the need for haemodialysis was lower (p = 0,008) and urine output was higher (p = 0,006). Furthermore in-hospital stay was shorter.

Conclusions: Infusions with recombinant BNP ameliorate the effects of BNP-depletion in TAH patients and contribute to a better renal function and a significantly decreased need for haemodialysis.