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Am J Perinatol 2010; 27(7): 525-528
DOI: 10.1055/s-0030-1248938
© Thieme Medical Publishers

Effect of Magnesium Sulfate Concentration on Serum Ionized Magnesium In Vitro

Mia Salamon1 , Francis B. Mimouni2 , 3 , Shaul Dollberg1 , 3 , Dror Mandel1 , 3
  • 1Department of Neonatology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  • 2Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel
  • 3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Publication History

Publication Date:
22 February 2010 (online)

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ABSTRACT

We undertook this in vitro study to quantify the effect that addition of magnesium (Mg) sulfate to neonatal serum, as compared with adult serum, might have on ionized Mg (Mg2+) concentration. We used one cord blood sample and one adult blood sample that we made hypermagnesemic by adding various amounts of magnesium sulfate to study five levels of serum Mg. Each sample was then studied at one of three levels of pH, from extreme alkalosis to extreme acidosis. We measured the changes in serum Mg2+ and serum ionized calcium (Ca2+) in reaction to these changes in pH and Mg. At each pH level, there was an exponential increase in the serum Mg2+ (and no significant change in serum Ca2+) with increasing serum Mg. Multiple regression analysis using Mg2+ as the dependent variable and baseline Ca2+, phosphorous, albumin, and blood type (adult versus cord blood) as well as blood pH and serum Mg as independent variables indicated that serum Mg and pH were the only variables significantly influencing serum Mg2+. Within the range of serum Mg considered, the addition of magnesium sulfate in vitro causes an exponential increase in Mg2+ and no significant change in serum Ca2+.

KEYWORDS

Magnesium supplementation - ionized magnesium

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Dror MandelM.D. M.H.A. 

Department of Neonatology, Lis Maternity Hospital, Tel Aviv-Sourasky Medical Center

6 Weizman Street, Tel Aviv, 64239, Israel

Email: dmandel@post.tau.ac.il

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