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Exp Clin Endocrinol Diabetes 1998; 106(6): 522-525
DOI: 10.1055/s-0029-1212027
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma

K. D. Dieterich, H. Lehnert
  • Dept. of Endocrinology and Metabolism, University Hospital Magdeburg, Germany
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Publication History

Publication Date:
14 July 2009 (online)

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Summary

Expression of leptin receptor (OB-R) mRNA was detected in the human anterior pituitary as well as in ACTH-secreting and nonsecreting pituitary adenomas by RT-PCR with primers recognizing all receptor splice variants. Primers specific to the long splice variant of the leptin receptor (OB-Rb), containing the putative intracellular signalling domain, also revealed a strong expression in normal and adenomatous anterior pituitaries. These results indicate that the pituitary is a possible target tissue of leptin action and might be involved in leptin regulation of pituitary hormone secretion.

Key words

Leptin - OB-R - receptor - pituitary - splice variant

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