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Horm Metab Res 1971; 3(4): 273-276
DOI: 10.1055/s-0028-1094147
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© Georg Thieme Verlag KG Stuttgart · New York

The Influence of Antiandrogens on the Excretion of FSH, LH and 17-Ketosteroids in Males

K.  Vosbeck , P. J. Keller
  • Hormonlaboratorien der Universitäts-Frauenklinik, Zürich, Switzerland
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

The excretion of FSH, LH and 17-ketosteroids was studied in healthy men before, during and after administration of antiandrogens, i.e. cyproterone-acetate and cyproterone. The first compound mainly decreased the FSH-activity and to a lower extent also the LH-activity in cases with comparatively high pretreatment levels, but did not clearly affect these hormones in other subjects. The excretion of 17-ketosteroids was not much altered. In contrast the free alcohol, cyporoterone, tended to increase the FSH- and LH-levels in some, the 17-ketosteroids in all cases.

The possible reasons for these effects, i.e. the dose dependency or different mode of action of the two compounds are discussed.

Key words

Antiandrogens - Cyproterone - Cyproterone Acetate - FSH - LH - 17-Ketosteroids

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