Sutherlandia frutescens (L.) R.Br. - Der Krebsbusch

 

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Zusammenfassung

Sutherlandia frutescens (L.) R.Br., der Krebsbusch (Fabaceae), ist seit langem in der traditionellen Medizin des südlichen Afrikas bekannt als Arzneipflanze zur Behandlung eines breiten Spektrums von Krankheiten, das von der Anwendung bei bestimmten Krebsarten, Virusinfektionen, Diabetes, zentralnervösen und gastrointestinalen Störungen bis hin zu Entzündungen und rheumatischen Erkrankungen reicht. In jüngster Zeit konnten mit Hilfe moderner wissenschaftlicher Methoden antioxidative, antiinflammatorische, hypoglykämische, antivirale und antiproliferative Effekte in vitro, teilweise auch in tierexperimentellen Studien nachgewiesen werden. Als Inhaltsstoffe wurden bisher u.a Aminosäuren, Zucker, Phenole, Sterole und ein Triterpensaponin identifiziert. Die Toxizität der nicht proteinogenen Aminosäure L-Canavanin, die häufiger aus Samen von Fabaceen der Unterfamilie Faboideae (syn. Papilionoideae) isoliert wurde, ist gut dokumentiert, jedoch sind in tierexperimentellen Studien bisher keine Hinweise auf toxische Effekte des Gesamtextraktes von S. frutescens registriert worden.

Summary

Sutherlandia frutescens (L.) R.Br., the cancer bush from the Fabaceae family, has been known in traditional medicine of southern Africa for a long time as a multipurpose medicinal plant for curing certain types of cancers, viral infections, diabetes, central nervous and gastrointestinal disorders, inflammations as well as rheumatic diseases. Recently, modern scientific methods have confirmed antioxidative, anti-inflammatory, hypoglycaemic, antiviral and anti-proliferative effects in vitro, partly also in animal models. Amino acids, sugars, phenols, sterols and a triterpensaponine have hitherto been identified as the ingredients. Despite the well documented toxicity of L-canavanine, a non-proteinogenic amino acid often found in seeds of members of the Fabaceae, subfamily Faboideae (syn. Papilionoideae), no toxic effects have been observed for the Sutherlandia frutescens-extract in animal models so far.

Literatur

• 1 Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes.  Diabetes Care. 1989;  12 553-564
  PubMedGoogle Scholar
• 2 Bell EA, Lackey JA, Polhill RM. Systematic significance of canavanine in the Papilionoideae (Faboideae).  Biochem Syst Ecol. 1978;  6 210-212
  PubMedGoogle Scholar
• 3 Bence AK, Worthen DR, Adams VR, Crooks PA. The antiproliferative effects of L-canavanine and L-canaline.  Anticancer Drugs. 2002;  13 313-320
  CrossrefPubMedGoogle Scholar
• 4 Bence AK, Crooks PA. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery.  J Enzyme Inhib Med Chem. 2003;  18 383-394
  CrossrefPubMedGoogle Scholar
• 5 Chinkwo KA. Sutherlandia frutescens extracts can induce apoptosis in cultured carcinoma cells.  J Ethnopharmacol. 2005;  98 163-170
  CrossrefPubMedGoogle Scholar
• 6 Curtis W. The botanical magazine: Colutea frutescens. Scarlett bladder-senna.  London: Couchman. 1792;  6
  PubMedGoogle Scholar
• 7 Ding Y, Matsukawa Y, Ohtani-Fujita N. et al. . Growth inhibition of A549 human lung adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction.  Jpn J Cancer Res. 1999;  90 69-74
  PubMedGoogle Scholar
• 8 Fernandes AC, Cromarty AD, Albrecht C, Jansen van Rensburg CE. The antioxidant potential of Sutherlandia frutescens.  J Ethnopharmacol. 2004;  95 1-5
  CrossrefPubMedGoogle Scholar
• 9 Goldblatt P, Manning JC. Cape plants. A conspectus of the Cape Flora of South Africa.  Strelitzia. 2000;  9 708
  PubMedGoogle Scholar
• 10 Hamburger M, Hostettmann K. Bioactivity in plants: the link between phytochemistry and medicine.  Phytochemistry. 1991;  30 3864-3874
  CrossrefPubMedGoogle Scholar
• 11 Harnett SM, Oosthuizen V, van de Venter M. Anti-HIV activities of organic and aqueous extracts of Sutherlandia frutescens and Lobostemon trigonus.  J Ethnopharmacol. 2005;  96 113-119
  CrossrefPubMedGoogle Scholar
• 12 Jang MH, Jun DY, Rue SW, Han KH, Park W, Kim YH. Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.  Biochem Biophys Res Com. 2002;  295 283-288
  PubMedGoogle Scholar
• 13 Jaume JH Saint-Hillaire. Traité des arbrisseaux et des arbustes cultivés en France et en plein. Paris: Eigenverlag 1825
  Google Scholar
• 14 Katerere DRP, Eloff JN. Antibacterial and antioxidant activity of Sutherlandia frutescens.  South African J Bot. 2003;  69 234
  PubMedGoogle Scholar
• 15 Kim Y, Gruen RS, MacDonald RS, Fernando LN. Antioxidative activities of Sutherlandia frutescens (subs. microphylla) extract. Abstract. Annual Congress of the Institute of Food Technologists, The Society for Food Science and Technology, Las Vegas 2004
  Google Scholar
• 16 Kundu JK, Mossanda KS, Na HK, Surh YJ. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.  Cancer Lett. 2005;  218 21-31
  CrossrefPubMedGoogle Scholar
• 17 Li X, Atkinson RN, King SB. Preparation and evaluation of new L-canavanine derivatives as nitric oxide synthase inhibitors.  Tetrahedron. 2001;  47 6557-6565
  PubMedGoogle Scholar
• 18 Mills E, Foster BC, Heeswijk RV. et al. . Impact of African herbal medicines on antiretroviral metabolism.  AIDS. 2005;  19 95-97
  PubMedGoogle Scholar
• 19 Morimoto I, Shiozawa S, Tanaka Y, Fujita T. L-Canavanine acts on suppressor-inducer T cells to regulate antibody synthesis: Lymphocytes of systemic lupus erythematosus patients are specifically unresponsive to L-canavanine.  Clin Immun Immunpath. 1990;  55 97-108
  PubMedGoogle Scholar
• 20 Moshe D, van der Bank H, van der Bank M, van Wyk BE. Lack of genetic differentiation between 19 populations from seven taxa of Sutherlandia tribe: Galegeae, Fabaceae.  Biochem Syst Ecol. 1998;  26 595-609
  PubMedGoogle Scholar
• 21 N. N.. Sutherlandia Frutescens Herba. Monographie. Last updated: 29-Apr-2004. www.sahealthinfo.org/traditionalmeds/monographs/sutherlandia.htm
  Google Scholar
• 22 N. N.. Sutherlandia frutescens. Monographie. Stand 4.11.2005. www.sutherlandia.com
  Google Scholar
• 23 N. N.. Sutherlandia frutescens. Monographie. Stand 4.11.2005. www.sutherlandia.org
  Google Scholar
• 24 N. N.. Agribusiness in sustainable natural African plant products (A-SNAPP). Stand: April 2000. www.cnrs.fr/DRI/Pretoria/Actualite/Notes/Agribusiness.htm
  Google Scholar
• 25 N. N.. Pharmaceuticals from plants: great potential, few funds [Editorial].  Lancet. 1994;  343 1513-1515
  CrossrefPubMedGoogle Scholar
• 26 Na HK, Mossanda KS, Lee JY, Surh YJ. Inhibition of phorbol ester-induced COX-2 expression by some edible African plants.  BioFactors. 2004;  21 149-153
  CrossrefPubMedGoogle Scholar
• 27 Neuwinger HD. Pflanzen zur Behandlung von Diabetes mellitus in der afrikanischen traditionellen Medizin - eine Übersicht.  Z Phytotherapie. 2004;  25 224-233
  PubMedGoogle Scholar
• 28 Ojewole JA. Analgesic, antiinflammatory and hypoglycemic effects of Sutherlandia frutescens R. BR. (variety incana E. MEY.) [Fabaceae] shoot aqueous extract.  Methods Find Exp Clin Pharmacol. 2004;  26 409-416
  PubMedGoogle Scholar
• 29 Phillips EP, Dyer RA. The genus Sutherlandia R.  Br. Rev SudAmer Bot. 1934;  1 69-80
  PubMedGoogle Scholar
• 30 Platel K, Srinivasan K. Plant foods in the management of Diabetes mellitus: vegetables as potential hypoglycaemic agents.  Nahrung. 1997;  41 68-74
  CrossrefPubMedGoogle Scholar
• 31 Prevoo D, Smith C, Swart P, Swart AC. The effect of Sutherlandia frutescens on steroidogenesis: confirming indigenous wisdom.  Endocrine Res. 2004;  30 745-751
  PubMedGoogle Scholar
• 32 Rosenthal GA. Metabolism of L-canavanine and L-canaline in leguminous plants.  Plant Physiol. 1990;  94 1-3
  PubMedGoogle Scholar
• 33 Rosenthal GA. The biochemical basis for the deleterious effects of L-canavanine.  Phytochemistry. 1991;  30 1055-1058
  CrossrefPubMedGoogle Scholar
• 34 Rosenthal GA. L-Canaline: a potent antimetabolite and anti-cancer agent from leguminous plants.  Life Science. 1997;  60 1635-1641
  CrossrefPubMedGoogle Scholar
• 35 Schrire BD, Andrew S. Sutherlandia: gansies or balloon peas: part 1.  The Plantsman. 1992;  14 65-69
  PubMedGoogle Scholar
• 36 Seier J, Mdhluli M, Dhansay MA. et al. .A toxicity study of Sutherlandia leaf powder (Sutherlandia microphylla) consumption. Final report April 2002. Studie mit Unterstützung des Medical Research Council of South Africa und der National Research Foundation. www.sahealthinfo.org/traditionalmeds/firststudy/htm
  Google Scholar
• 37 Sia C. Spotlight on ethnomedicine: Usability of Sutherlandia frutescens in the treatment of diabetes.  Rev Diab Stud. 2004;  1 145-149
  CrossrefPubMedGoogle Scholar
• 38 Swaffar DS, Ang CY. Growth inhibitory effect of L-canavanine against MIA PaCa.2 pancreatic cancer cells is not due to conversion to its toxic metabolite canaline.  Anticancer Drugs. 1999;  10 113-118
  PubMedGoogle Scholar
• 39 Tai J, Cheung S, Chan E, Hasman D. In vitro culture studies of Sutherlandia frutescens on human tumor cell lines.  J Ethnopharmacol. 2004;  93 9-19
  CrossrefPubMedGoogle Scholar
• 40 Thomas DA, Rosenthal GA, Gold DV, Dickey K. Growth inhibition of a rat colon tumor by L-canavanine.  Cancer Res. 1986;  46 2898-2903
  PubMedGoogle Scholar
• 41 Thomson S. Canavanine toxicity: is Sutherlandia a healthy herb or potent(ial) poison? HIV positives and AIDS sufferers beware: the remedy may be worse than the alleged disease. Gaia Research Institute. www.gaiaresearch.co.za/sutherlandia.html 2002
  Google Scholar
• 42 Thomson S. Sutherlandia »fails« safety test. Gaia Research Institute. www.gaiaresearch.co.za/sutherlandia.html 2002
  Google Scholar
• 43 Turner BL, Harborne JB. Distribution of canavanine in the plant kingdom.  Phytochemistry. 1967;  6 863-866
  CrossrefPubMedGoogle Scholar
• 44 van Wyk BE, van Oudtshoorn B, Gericke N. Medicinal Plants of South Africa. Pretoria: Briza Publications 1997: 246-247
  Google Scholar
• 45 Watt C, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Edinburgh, London: Livingstone 1962: 649
  Google Scholar
• 46 Xaba PMA, Notten A. Sutherlandia frutescens (L.) R. Br. Monographie vom April 2003. www.plantzafrica.com/plantqrs/sutherfrut.htm 2003
  Google Scholar

Dr. Klaus Peter Latté

Apotheker

Warägerweg 21

13595 Berlin

Email: klauspeter.latte@lycos.de