Regular ArticleMycobacteriophage TM4: genome structure and gene expression
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Phages for the treatment of Mycobacterium species
2023, Progress in Molecular Biology and Translational SciencePhage engineering for development of diagnostic tools
2023, Progress in Molecular Biology and Translational ScienceGp29 LysA of mycobacteriophage TM4 can hydrolyze peptidoglycan through an N-acetyl-muramoyl-L-alanine amidase activity
2022, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :This high structural diversity and modular organization of mycobacteriophage endolysins could be related to the complex cell wall present in their hosts. The lysis module in bacteriophage TM4, is composed of the products of gp29-gp30-gp31 coding for putative LysA, LysB and holin, respectively [19,20]. According to Payne and Hatfull [15] analysis, gp29 LysA of TM4 falls into the Org-K organization, where the N-terminal domain is classified as N2, showing similarity to known peptidases (but not to any currently identified conserved domain) and proposed as a putative hydrolase (M23B peptidase); the central domain is Ami2B (related to the amidase-2 conserved domain-pfam01510) and the C-terminal domain, where other phage endolysins typically have a cell wall binding domain, has a C1 motif but lacks any recognizable conserved domain or HHPred [21,22] match.
Mycobacteriophage ZoeJ: A broad host-range close relative of mycobacteriophage TM4
2019, TuberculosisCitation Excerpt :Little is known about the host range of the other Cluster K phages, although some of them replicate poorly at temperatures above 30 °C (e.g. Anaya), conditions that are not conducive for M. tuberculosis growth. TM4 is a Subcluster K2 phage which has been used extensively as a tool for mycobacterial genetics [11,12]. Although most Cluster K phages are temperate, TM4 forms clear plaques and does not form stable lysogens [10,11].