Clinical Papers
Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature

https://doi.org/10.1054/ijom.2002.0206Get rights and content

Abstract

Abstract.

The aim of this study is to report on five cases of intraoral pleomorphic adenoma (PA) in patients under 18 years of age and to review the literature. Intraoral salivary gland tumours were reviewed in two Brazilian institutions and five cases of PA in patients under 18 years of age were found. Clinical data were obtained from the medical records and paraffin-embedded tissues were sectioned for proliferating cell nuclear antigen (PCNA) and p53 immunohistochemical analysis. Four patients were female and one was male; two cases affected the palate, two the upper lip and one the tongue. All five patients were treated surgically and after long follow-up periods no recurrences were observed. Tumour cells were weakly positive for PCNA and negative for p53. PA should be considered in the differential diagnosis of submucosal nodules in young patients. In youngsters, PA seems to have similar biological characteristics as in adults, with low recurrence rates after surgical resection.

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Address: Luiz Paulo Kowalski MD, PhD, Department of Head and Neck Surgery and Otorhinolaryngology, AC Camargo Hospital, Rua Professor Antônio Prudente, 211 Liberdade, São Paulo/SP, CEP: 01509-010, Brazil, Tel: +55 11 3272 5125; Fax: +55 11 3277 6789; E-mail: lp–[email protected]

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Copyright © 2002 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.