Original ArticleAsymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality☆
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Cited by (226)
ADMA and homoarginine independently predict mortality in critically ill patients
2022, Nitric Oxide - Biology and ChemistryCitation Excerpt :Arginine, methylated arginines and homoarginine are important modulators of the nitric oxide pathway. Most interest has focused on asymmetric dimethyl-l-arginine (ADMA), which is a potent inhibitor of nitric oxide synthase, and its plasma concentration has been positively associated with mortality in healthy adults [5] and many patient groups including those with acute coronary syndrome [6], acute infection [7–10] and end-stage renal failure [11]. Monomethyl-l-arginine (MMA) also inhibits nitric oxide synthase, and was previously shown to increase mortality when used therapeutically in acute myocardial infarction [12], cardiogenic shock [12] and septic shock [13].
Regulation: Transcriptional and post-translational regulation of the dimethylarginines ADMA and SDMA and their impact on the L-arginine - Nitric oxide pathway
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Grant/fellowship: R.J. Nijveldt, MD, is a recipient of a fellowship from the Council for Medical Research of the Netherlands Organisation for Scientific Research
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(Correspondence to: PAML, Department of Surgery, VU Medical Center, Institute for Cardiovascular Research-VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands)