Elsevier

Placenta

Volume 23, Issue 6, July 2002, Pages 497-502
Placenta

Regular Articles
Antioxidative Collagen-Derived Peptides In Human-Placenta Extract

https://doi.org/10.1053/plac.2002.0833Get rights and content

Abstract

Human-placenta extract (PLx), has been widely used in clinical and cosmetic fields, and is known to possess marked antioxidant activity. We have attempted to identify the antioxidative components in PLx. Initially, we purified PLx using Sephadex G-10 column. The first eluted peak which had optical density at 280 nm and exhibited approximately 20 per cent of antioxidant activity of the applied PLx, did not contain uracil, tyrosine, phenylalanine, or tryptophan which are the previously identified antioxidants from PLx. This fraction was further purified by reverse-phase high performance liquid chromatography. All eluted peaks containing antioxidant activity exhibited optical density at 280 nm. Six separate fractions of eluent having antioxidant activity were analyzed by an amino acid sequencer, and each turned out to contain Glycine(G)-XY amino acid repeats, which appear to be derived from collagen. These results suggest that peptides produced from collagen are also antioxidative components of PLx.

References (21)

There are more references available in the full text version of this article.

Cited by (77)

  • Effects of Lamb Placenta Peptide Powder on Skin Moisturizing and Wrinkle Formation

    2023, Journal of the Korean Society of Food Science and Nutrition
  • Amino Acid Composition of Melagenin Plus®

    2023, Revista Cubana de Farmacia
View all citing articles on Scopus
f1

To whom correspondence should be addressed at: Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-Chome, Shinagawa-ku, Tokyo 142-8501, Japan. Tel./Fax: +81-3-5498-5950; E-mail:[email protected]

View full text