Regular ArticlesDose-dependent Responses of Sheep Inoculated Intranasally with a Type O Foot-and-mouth Disease Virus
References (24)
- et al.
The suitability of the “emergency” foot-and-mouth disease antigens held by the International Vaccine Bank within a global context
Vaccine
(2001) - et al.
Emergency vaccination of sheep against foot-and-mouth disease: protection against disease and reduction in contact transmission
Vaccine
(1999) - et al.
Routine application of enzyme-linked immunosorbent assay in comparison with complement fixation for the diagnosis of foot-and-mouth and swine vesicular diseases
Veterinary Microbiology
(1988) - et al.
The 1975 foot-and-mouth disease epidemic in Malta. II: the detection of carriers and inapparent infection
British Veterinary Journal
(1981) - et al.
Exposure of sheep to natural aerosols of foot-and-mouth disease virus
Research in Veterinary Science
(1986) - et al.
A new enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. I. Development and method of ELISA
Journal of Immunological Methods
(1986) - et al.
Removal of false positive reactions from plasma in an enzyme immunoassay for bovine interferon-gamma
Journal of Immunological Methods
(1992) - et al.
Detection and typing of foot-and-mouth disease virus by enzyme-linked immunosorbent assay: a sensitive, rapid and reliable technique for primary diagnosis
Research in Veterinary Science
(1987) - et al.
The airborne dispersal of foot and mouth disease virus from vaccinated and recovered pigs, cattle and sheep after exposure to infection
Research in Veterinary Science
(1977) - et al.
The role of sheep and goats in the epizootiology of foot and mouth disease in Kenya
Journal of Hygiene, Cambridge
(1976)
The persistence of foot-and-mouth disease virus in sheep
Journal of Hygiene, Cambridge
Clinical and anatomical manifestations of foot and mouth disease in new-born lambs
Trudy Ulyanov Sel»khozmashiny Instituta Zootechologii Veterinaria
Cited by (18)
Dose–response modelling of infectious animal diseases coupled with computational fluid dynamics: A simulation of airborne porcine reproductive and respiratory syndrome virus
2021, Biosystems EngineeringCitation Excerpt :Dose–response modelling of FMDV indicated that the pathogen was less infectious to sheep by the intra-nasal transmission route (Fig. 7a) than the aerosol transmission route (Fig. 7b). It should be noted that the difference between the intra-nasal and aerosol infectiousness might also be due to different virus strains used in the intra-nasal experiments (Hughes et al., 2002) and the aerosol experiments (Gibson & Donaldson, 1986). The dose–response models of FMDV in cows by exposure to naturally generated (Fig. 7c) and artificially generated (Fig. 7d) aerosols were similar, with differences only in the 2.5-percentile curves, which might be due to the use of different virus strains for the natural and artificial aerosol exposures (Donaldson et al., 1987).
Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems
2015, Veterinary MicrobiologyCitation Excerpt :Similarly detailed tissue-based investigations of FMDV in sheep have not been performed, although it has generally been assumed that critical events of FMDV pathogenesis in small ruminants are similar to those described for cattle (Alexandersen et al., 2003b; Arzt et al., 2011). Previous studies have confirmed that sheep are susceptible to FMDV infection via nasal instillation (Hughes et al., 2002a; McVicar and Sutmoller, 1971) and exposure to naturally generated aerosols (Aggarwal et al., 2002; Gibson and Donaldson, 1986; Gibson et al., 1984), in addition to coronary band injection and contact exposure (Alexandersen et al., 2002; Burrows, 1968; Horsington et al., 2015). However, the use of different challenge viruses at varying doses generally precludes detailed comparisons of experimental systems based on these works.
Modeling inoculum dose dependent patterns of acute virus infections
2014, Journal of Theoretical BiologyModelling the within-host growth of viral infections in insects
2012, Journal of Theoretical BiologyCitation Excerpt :Therefore, transmission is likely to be maximised for some intermediate dose. Our result also contrasts with vertebrate within-host theory, where Steinmeyer et al. (2010) found that increasing viral dose increased the peak viral load, whilst empirical evidence suggests the contrary, as found in sheep inoculated intranasally with a type O foot-and-mouth disease virus (Hughes et al., 2002). Here the authors suggested the reason for this is that cell-mediated immune mechanisms responded more quickly to high doses than lower doses, the result being increased inhibition of viral replication.
Foot-and-Mouth Disease Virus Infection in Fetal Lambs: Tissue Tropism and Cytokine Response
2008, Journal of Comparative PathologyCitation Excerpt :Interestingly, TNF-α has been associated with FMDV-induced apoptosis in infected pigs (Ku et al., 2005). In sheep, studies of cytokines and FMDV have been confined to quantifying IFN-γ in serum during infection and following vaccination (Hughes et al., 2002; Barnett et al., 2004). The literature on cytokine expression in normal pregnant sheep focuses on the modulation of the maternal immune response to allow successful embryonic implantation and development.
Foot and mouth disease virus transmission among vaccinated pigs after exposure to virus shedding pigs
2007, VaccineCitation Excerpt :A difference in success rate of infection dependent on route of exposure has also been shown for respiratory viruses in humans, in which volunteers were directly (nasopharyngeal instillation) and indirectly (airborne) exposed to respiratory viruses [17]. Other studies have been performed to identify the minimal infectious dose for several FMD virus strains in cattle, sheep and pigs and infectious doses as low as 10 TCID50 were identified for calves [18–21], but limited data on the impact of duration of exposure have been published. Burrows et al. compared several challenge methods and hypothesized that an overwhelming amount of virus by contact-exposure to a clinically infected animal might lead to simultaneous infection of different sites in the animal and thereby lead to more severe clinical signs [22].
- f1
Correspondence to: G. J. Hughes, Division of Viral and Rickettsial Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G33, Atlanta, GA 30333, USA.