Pediatric Epilepsy: Neurology, Functional Imaging, and Neurosurgery
Section snippets
18F-FDG-PET Imaging in Epilepsy
18F-FDG-PET is a tracer capable of measuring brain glucose metabolism and is actively transported across the blood-brain barrier into brain cells for subsequent phosphorylation. The relatively long half-life of 18F of 109 minutes permits transport from one cyclotron production facility to several sites within 2-4 hours of travel distance. A normal FDG-PET scan in coronal section is shown in Figure 2.
Rationale for Intracranial EEG Monitoring
The next step in the workup of a potential patient for epilepsy surgery is a comprehensive and multidisciplinary review of all noninvasive clinical, radiological, and electrophysiological data. In most instances, the results of the noninvasive assessment are sufficient to arrive at a resective surgical plan. Within the realm of pediatric epilepsy surgery, however, numerous scenarios arise where information from chronic invasive intracranial EEG recordings is required to formulate an optimal
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FOXD3 inhibits SCN2A gene transcription in intractable epilepsy cell models
2018, Experimental NeurologyCitation Excerpt :Moreover, epilepsy has become one of the most common diseases of the nervous system (Dossi et al., 2017; Srinivas and Shah, 2017). The pathogenesis of epilepsy is very complex and involves a series of physiological, biochemical, immune, and genetic changes (Dubey et al., 2017; Mountz et al., 2017; Nass et al., 2017). Recent studies have found that many cases of epilepsy are caused by mutations in genes that code for ion channel proteins (Kingston and Schwedt, 2017; Kumar and Chugani, 2017a, 2017b).
Letter From the Guest Editor
2017, Seminars in Nuclear MedicineChallenging Cases in Paediatric Radiology
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2022, Handbook of Pediatric EpilepsyInterictal and postictal<sup>18</sup>F-FDG PET/CT in epileptogenic zone localization
2022, Radiologia BrasileiraCase Report: Aperiodic Fluctuations of Neural Activity in the Ictal MEG of a Child With Drug-Resistant Fronto-Temporal Epilepsy
2021, Frontiers in Human Neuroscience