Renal and Pulmonary Late Effects of Cancer Therapy
Section snippets
Epidemiology
Renal dysfunction is an important consequence of cancer and its treatment, which may limit the ability to deliver optimal treatment and, if persistent, increase the morbidity and mortality, as well as reduce the quality of life, of long-term survivors. Even apparently reversible acute kidney injury may increase the likelihood of chronic renal disease later in life.1 Cancer itself may cause renal impairment due to renal infiltration, urinary tract obstruction, hypercalcemia, or the consequences
Epidemiology
Much of the existing knowledge about the chronic effects of cancer treatment on the lung comes from literature pertaining to studies on childhood cancer survivors. The Childhood Cancer Survivor Study (CCSS), a large retrospective cohort study of survivors of childhood and adolescent cancers, has demonstrated that the risk of pulmonary conditions is more than three times higher in cancer survivors than in their siblings.70 Lung disease may appear decades after treatment and is associated with
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Cited by (24)
Cardiovascular and Pulmonary Challenges After Treatment of Childhood Cancer
2020, Pediatric Clinics of North AmericaCitation Excerpt :The subsequent phase II study confirmed that the FAM-regimen with reduced doses of systemic steroids was well tolerated and resulted in a reduction in pulmonary function decline in most patients.99 Systemic steroid therapy improves radiation pneumonitis, but most experts agree that corticosteroid therapy is ineffective for the treatment of pulmonary fibrosis.71,73 A few newer drugs, such as the TKI nintedanib, are available for adults with idiopathic pulmonary fibrosis.
Acute kidney injury from contrast-enhanced CT procedures in patients with cancer: white paper to highlight its clinical relevance and discuss applicable preventive strategies
2020, ESMO OpenCitation Excerpt :Beyond anticancer agents, oncological patients are indeed exposed to multiple nephrotoxic insults, including antibiotics, analgesics and drugs for supportive therapy (eg, bisphosphonates). Cisplatin is by far the most common cause of acute nephrotoxicity from anticancer agents; it typically causes glomerular impairment and tubulopathy, which ultimately leads to magnesuria and hypomagnesaemia.16 The incidence and severity of renal toxicity increases with the repeated use of cycles of cisplatin-based chemotherapy, ultimately leading to an irreversible damage.
Childhood cancer survivors: Considerations for surgeons in the transition from pediatric to adult care
2015, Seminars in Pediatric SurgeryCitation Excerpt :Nephrectomy may also be necessary for adrenal neuroblastoma in which the adrenal gland cannot be resected off of the underlying kidney. Nephrectomy may affect future renal function, although this relationship is confounded by the impact of nephrotoxic chemotherapy (e.g., ifosfamide) and RT on renal function.17 Genetic predisposition to both Wilms tumor and renal dysfunction (e.g., WT1 gene mutations) may also modify this relationship.
Analysis of risk factors for fatal renal complications after allogeneic hematopoietic cell transplantation
2024, Bone Marrow TransplantationPrevention of post-contrast kidney injury in patients with cancer
2024, Drugs in Context
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