Brief CommunicationPrevalence and Risk Factors of Nonalcoholic Fatty Liver Disease and Advanced Fibrosis in General Population: the French Nationwide NASH-CO Study
Section snippets
Materials and Methods
We conducted a cross-sectional study on data at baseline collected from participants included in the CONSTANCES cohort between 2012 and 2018. CONSTANCES is a “generalist” epidemiological cohort designed to be representative of the general French population consisting of a sample of more than 200,000 adults aged 18 years and older at baseline, and residing in 21 departments that hold a Health Screening Center (HSC) in France2 (Supplementary Methods). At inclusion, the selected subjects were
Results
At the time of analysis, 163,426 subjects had responded to the invitation letter and data were available in 119,150 participants. Sociodemographic characteristics were similar between participants and the overall responders (data not shown). After excluding subjects who had withdrawn their consent, had a history of excessive alcohol consumption defined by daily consumption more than 30 g/d in men and 20 g/d in women (n = 11,618), or chronic viral hepatitis (1108 hepatitis B virus, 560 hepatitis
Discussion
NAFLD affects almost one-fifth of a large French adult population-based cohort with no excessive alcohol consumption or chronic viral hepatitis. To our knowledge, this is the largest European survey evaluating NAFLD and advanced fibrosis in the general population. The CONSTANCES population-based cohort is a very large and representative survey of French general security regime (RG) affiliates aged 18 and older, representing approximately 50 million people.2 The lower than expected prevalence of
CRediT Authorship Contributions
Oumarou Nabi, PhD (Formal analysis: Lead; Methodology: Equal; Writing – original draft: Supporting). Karine Lacombe, MD,PhD (Conceptualization: Equal; Formal analysis: Lead; Methodology: Equal; Writing – original draft: Equal). Jerome Boursier, MD,PhD (Methodology: Supporting; Writing – original draft: Supporting; Writing – review & editing: Equal). Philippe Mathurin, MD, PhD (Writing – original draft: Equal; Writing – review & editing: Equal). Marie Zins, PhD (Writing – review & editing:
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Conflicts of interest The authors disclose no conflicts.
Funding The Constances Cohort Study is supported and funded by the Caisse nationale d’assurance maladie (CNAM). The Constances Cohort Study is an “Infrastructure nationale en Biologie et Santé” and benefits from a grant from ANR (ANR-11-INBS-0002) and from the Ministry of Research. Constances is also partly funded by MSD, AstraZeneca and Lundbeck.
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Authors share co-first authorship.