Abstract
BACKGROUND: Disclosure of medical research results to the public creates tension between lay medical reporters and the medical profession.
OBJECTIVE: To explore the early effect of media attention on the risks associated with short-acting calcium channel blockers (CCBs) for treating hypertension after publication at a national meeting and following publication.
DESIGN: Time-series analysis of prescription claims data.
SETTING AND DATA SOURCE: National third-party pharmaceutical benefits manager.
PATIENTS: Employed or retired persons and their families, 18 years of age or older, receiving prescription benefits from 1 of 4 national companies that contracted with the pharmaceutical benefits manager exclusively for prescription drug coverage.
MEASUREMENTS: Prescription claims for antihypertensive drugs by fill date converted to a percentage of all cardiovascular drug claims. Data were grouped into weekly intervals before and immediately after the national release of negative information about CCBs on March 10, 1995 and following publication of the results on August 23, 1995.
RESULTS: The most prevalent antihypertensive drugs were diuretics (21% of cardiovascular prescription claims) and calcium channel blockers (19%). A 10% decline in prescriptions filled for CCBs occurred 4 weeks following the intense media attention. Only prescriptions for long-acting calcium channel blockers declined. Alpha-1-blocker prescriptions increased by approximately the same amount that prescriptions for CCBs declined, suggesting substitution of one drug for the other. Changes in diuretic or β-blocker prescriptions filled were not statistically significant. No immediate change in other cardiovascular drug classes occurred following journal publication.
CONCLUSIONS: Intense media publicity regarding a controversial study measurably and unpredictably changed prescription claims.
Similar content being viewed by others
References
Definition of “Sole Contribution.” N Engl J Med. 1969;281:676–7.
Relman AS. The Ingelfinger Rule. N Engl J Med. 1981;305:824–6. Editorial.
Angell M, Kassirer JP. The Ingelfinger rule revisited. N Engl J Med. 1991;325:1371–3. Editorial.
Fletcher RH, Fletcher SW. Medical journals and society: threats and responsibilities. Intern Med. 1992;232:215–21.
Fletcher SW, Fletcher RH. Early release of research results. Ann Intern Med. 1991;114:698–700. Editorial.
Altman LK. The Ingelfinger rule, embargoes, and journal peer review. Part 1. Lancet. 1996;347:1382–6.
Altman LK. The Ingelfinger rule, embargoes, and journal peer review. Part 2. Lancet. 1996;347:1459–63.
Psaty BM, Heckbert SL, Koepsell TD, et al. The risk of incident myocardial infarction associated with anti-hypertensive drug therapies. Circulation. 1995;91:925. Abstract.
Psaty BM, Heckbert SR, Koepsell TD, et al. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA. 1995;274:620–5.
Mittler B. Dangerous medicine. Forbes Mediacritic. 1995;3:72–8.
Shuchman M, Wilkes MS. Medical scientists and health news reporting: a case of miscommunication. Ann Intern Med. 1997;126:976–82.
Lenfant C. The calcium channel blocker scare. Lessons for the future. Circulation. 1995;91:2855–6.
Parmley WW. Sensationalism and the news media. J Am Coll Cardiol. 1995;26:836–7. Editorial.
Byrd J. Scared readers. The Washington Post. March 26, 1995:Final Edition C06.
Colburn D. Controlling your high blood pressure; reports cause furor by linking some drugs to heart attack risk. The Washington Post. March 28, 1995:Final Edition Z10.
Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med. 1993;153:154–83.
Raeburn P. Widely used blood pressure drugs may increase heart attack risk. The Associated Press. San Antonio. March: 10, 1995.
King W. Risk cited for blood pressure drug—chances higher for heart attack. The Seattle Times. March 10, 1995:Final Edition B1.
Kolata G. Heart attacks may have tie to drug type. The New York Times. March 12, 1995: Section 1;Late Edition 27.
McGrath M. Heart attack blamed on halt in medication. Omaha World Herald. March 17, 1995:Sunrise Edition 14.
Bier J. Blood pressure drugs’ risks downplayed. The Frenso Bee. March 15, 1995: Home Edition A1.
Sulmasy DP. The impact of media coverage on practice. J Gen Intern Med. 1996;11:62. Letter.
Furberg CD, Psaty BM, Meyer JV. Nifedipine: dose-related increase in mortality in patients with coronary heart disease. Circulation. 1995;92:1326–31.
The National Heart, Lung, and Blood Institute. New analyses regarding the safety of calcium-channel blockers: a statement for health professionals. September 1, 1995. Available at: http://www.nhlbi.nih.gov/new/press/cutlrccb.txt. Accessed December 10, 2002.
Raeburn P, Study says high doses of heart drug nearly triple death rate. The Associated Press. August 31, 1995.
Altman LK. Agency issues warning for drug widely used for heart disease. The New York Times. September 1, 1995: Late Edition—Final 1.
Bishop J. National Heart Institute warns against using high doses of blood pressure drug. Wall Street Journal. September 1, 1995: B6.
Akaike H. A new look at the statistical model identification. IEEE Transaction on Automatic Control. 1974;AC19:716–23.
Maclure M, Dormuth C, Naumann T, et al. Influences of educational interventions and adverse news about calcium-channel blockers on first-line prescribing of antihypertensive drugs to elderly people in British Columbia. Lancet. 1998;352:943–8.
ALLHAT Collaborative Research Group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs. chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) JAMA. 2000;283: 1967–75.
Lepor H, Auerbach S, Puras-Baez A, et al. A randomized, placebocontrolled multicenter study of the efficacy and safety of terazosin in the treatment of benign prostatic hyperplasia. J Urol. 1992;148:1467–74.
Gillenwater JY, Conn RL, Chrysant SG, et al. Doxazosin for the treatment of benign prostatic hyperplasia in patients with mild to moderate essential hypertension: a double-blind, placebo-controlled, dose-response multicenter study. J Urol. 1995;154:110–5.
Fawzy A, Braun K, Lewis GP, Gaffney M, Ice K, Dias N. Doxazosin in the treatment of benign prostatic hyperplasia in normotensive patients: a multicenter study. J Urol. 1995;154:105–9.
Oxman AD, Thomson MA, Davis D, Haynes RB. No magic bullets: a systematic review of 102 trials of interventions to improve professional practice. CMAJ. 1995;153:1423–31.
Entwistle V. Reporting research in medical journals and newspapers. BMJ. 1995;310:920–3.
Phillips DP, Kanter EJ, Bednarczyk B, Tastad PL. Importance of the lay press in the transmission of medical knowledge to the scientific community. N Engl J Med. 1991;325:1180–3.
Author information
Authors and Affiliations
Corresponding author
Additional information
This study was funded under a research contract with Caremark, Inc. Caremark had no control over the hypotheses investigated or the conduct of the study. At the time of the study, Caremark was a third-party prescription service and had no links to a pharmaceutical company. Caremark had the right to review this manuscript for consideration of proprietary interests. The opinions expressed herein do not necessarily represent those of Caremark, Inc. or those of the participating institutions.
Rights and permissions
About this article
Cite this article
Brunt, M.E., Murray, M.D., Hui, S.L. et al. Mass media release of medical research results. J GEN INTERN MED 18, 84–94 (2003). https://doi.org/10.1046/j.1525-1497.2003.20502.x
Issue Date:
DOI: https://doi.org/10.1046/j.1525-1497.2003.20502.x