Issue 20, 1975
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Microbiological hydroxylation. Part XX. Hydroxylation of dioxygenated 5α-androstanes with the fungi Absidia regnieri and Syncephelastrum racemosum

Alan M. Bell,   SirEwart R. H. Jones,   G. Denis Meakins,   John O. Miners  and  Alistair L. Wilkins  

Abstract

Dioxygenated androstanes are readily hydroxylated by the title fungi. Although complex mixtures are generally formed, 3β-hydroxy-5α-androstan-7-one is converted efficiently into its 12α-hydroxy-derivative (51% yield) by S. racemosum. The poor steroid recoveries of incubations involving 3,17-dioxygenated substrates and A. regnieri are improved by using a medium containing cobalt(II) sulphate: under such conditions 3β-hydroxy-5α-androstan-17-one gives 3β,9α-dihydroxy-5α-androstan-17-one in 49% yield.

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Article information

DOI
https://doi.org/10.1039/P19750002040
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1975, 2040-2043

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Microbiological hydroxylation. Part XX. Hydroxylation of dioxygenated 5α-androstanes with the fungi Absidia regnieri and Syncephelastrum racemosum

A. M. Bell, E. R. H. Jones, G. D. Meakins, J. O. Miners and A. L. Wilkins, J. Chem. Soc., Perkin Trans. 1, 1975, 2040 DOI: 10.1039/P19750002040

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