Issue 8, 1995
From the journal:

Journal of the Chemical Society, Dalton Transactions

Electron spin resonance study of the binding structures of cationic water-soluble metalloporphyrins on highly oriented deoxyribonucleic acid fibres

Makoto Chikira,   Shoichi Suda,   Toyotaka Nakabayashi,   Yoshihito Fujiwara,   Takashi Ejiri,   Mitsuhide Yoshikawa,   Nagao Kobayashi  and  Heisaburo Shindo  

Abstract

The binding structures of several paramagnetic metal complexes of 5,10,15,20-tetrakis(1-methyl-4-or -2-pyridinio) porphyrin (H2L1 or H2L2) on the highly oriented DNA fibres were investigated by means of ESR spectroscopy and computer simulations of the spectra. The structural parameters characteristic of the sterospecific groove binding were obtained for [CuL2]Cl4, high-spin [FeCl(L1)]Cl4 and low-spin [CoL1][ClO4]4 and the low-spin monoimidazole adduct [CoL1(Him)][ClO4]4. They bind to the DNA with the normals of the porphyrin planes titled by about 45° from the double helix axes. The low-spin bis(imidazole) adduct [FeCl(L1)(Him)2]Cl4 binds to A-form DNA with the porphyrin plane nearly parallel to the double helix axis. The complex [CoL1][ClO4]4 binds to DNA as an intercalator as well as a groove binder. It was also revealed that some metalloporphyrins stabilize the tertiary structures of DNA around the binding sites.

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Article information

DOI
https://doi.org/10.1039/DT9950001325
Article type
Paper

J. Chem. Soc., Dalton Trans., 1995, 1325-1331

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Electron spin resonance study of the binding structures of cationic water-soluble metalloporphyrins on highly oriented deoxyribonucleic acid fibres

M. Chikira, S. Suda, T. Nakabayashi, Y. Fujiwara, T. Ejiri, M. Yoshikawa, N. Kobayashi and H. Shindo, J. Chem. Soc., Dalton Trans., 1995, 1325 DOI: 10.1039/DT9950001325

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