Issue 18, 2024

Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

Abstract

We have developed a nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates that gives syn-β-cyanoalkenes. DFT calculations suggest that a favored transition state promotes Cα–H bond formation for determining regio- and stereoselectivity of the products.

Graphical abstract: Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2024
Accepted
09 Apr 2024
First published
16 Apr 2024

Org. Biomol. Chem., 2024,22, 3606-3610

Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

S. Arai, K. Nakazawa, X. Yang, M. Nakajima, S. Harada and A. Nishida, Org. Biomol. Chem., 2024, 22, 3606 DOI: 10.1039/D4OB00380B

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