Copper-catalyzed dehydrogenative cyclization/alkenylation towards dihydroquinolinones†
Abstract
An efficient copper-catalyzed one-pot sequential synthesis of alkenylated quinolinyl dihydroquinolinones is reported, utilizing ketones, 1,3-cyclohexanediones, and benzyl alcohols via dehydrogenative cyclization, followed by alkenylation. This highly straightforward method provides a mild and environmentally friendly approach, and scalable reactions are carried out without generating side products. Furthermore, a plausible reaction mechanism is proposed based on control-experiment studies and reaction monitoring via1H NMR analysis. In addition, the photophysical behavior of the synthesized products showed various responses in the absorption and emission spectra. Upon further examination, compound 4F was found to have acidochromic properties, leading to noticeable colour changes.
- This article is part of the themed collection: Celebrating the scientific accomplishments of RSC Fellows
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