Issue 40, 2024
From the journal:

Chemical Communications

A two carbon homologation of Friedel–Crafts alkylation enabled by photochemical alkene stitching: modular assembly of cyclolignans†

Shyamal Pramanik,a   Apurba Samantaa  and  Soumitra Maity ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM), Dhanbad, Jharkhand 826004, India
E-mail: smaity@iitism.ac.in

Abstract

Herein we report an efficient two-carbon homologated variant of Friedel–Crafts alkylation via photochemical radical alkene stitching. Readily available feedstock alkenes are used as bridges between photogenerated alkyl radicals and arenes, opening a route to γ-aryl-carbonyls for chemo-divergent access to aryltetralone and γ-lactones, a gateway to 2,7′-cyclolignans.

Graphical abstract: A two carbon homologation of Friedel–Crafts alkylation enabled by photochemical alkene stitching: modular assembly of cyclolignans

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Article information

DOI
https://doi.org/10.1039/D4CC00957F
Article type
Communication
Submitted
29 Feb 2024
Accepted
17 Apr 2024
First published
18 Apr 2024

Chem. Commun., 2024,60, 5282-5285

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A two carbon homologation of Friedel–Crafts alkylation enabled by photochemical alkene stitching: modular assembly of cyclolignans

S. Pramanik, A. Samanta and S. Maity, Chem. Commun., 2024, 60, 5282 DOI: 10.1039/D4CC00957F

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