Gingerol extract-stabilized silver nanoparticles and their applications: colorimetric and machine learning-based sensing of Hg(II) and antibacterial properties

Kittiya Plaeyao; Ratchaneekorn Kampangta; Yuparat Korkokklang; Chanon Talodthaisong; Apichart Saenchoopa; Saengrawee Thammawithan; Krailikhit Latpala; Rina Patramanon; Navaphun Kayunkid; Sirinan Kulchat

doi:10.1039/D3RA02702C

Gingerol extract-stabilized silver nanoparticles and their applications: colorimetric and machine learning-based sensing of Hg(ii) and antibacterial properties†

Kittiya Plaeyao,^a Ratchaneekorn Kampangta,^a Yuparat Korkokklang,^a Chanon Talodthaisong,^a Apichart Saenchoopa,^a Saengrawee Thammawithan,^b Krailikhit Latpala,^c Rina Patramanon,

^b Navaphun Kayunkid^d and Sirinan Kulchat

*^a

Author affiliations

* Corresponding authors

^a Materials Chemistry Research Center, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
E-mail: sirikul@kku.ac.th

^b Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand

^c Department of Mathematics, Faculty of Education, Sakon Nakhon Rajabhat University, Sakon Nakhon, Thailand

^d College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang, Ladkrabang, Bangkok 10520, Thailand

Abstract

This study focused on synthesizing ginger-stabilized silver nanoparticles (Gin-AgNPs) using a more eco-friendly method that utilized AgNO₃ and natural ginger solution. These nanoparticles underwent a color change from yellow to colorless when exposed to Hg²⁺, enabling the detection of Hg²⁺ in tap water. The colorimetric sensor had good sensitivity, with a limit of detection (LOD) of 1.46 μM and a limit of quantitation (LOQ) of 3.04 μM. Importantly, the sensor operated accurately without being affected by various other metal ions. To enhance its performance, a machine learning approach was employed and achieved accuracy ranging from 0% to 14.66% when trained with images of Gin-AgNP solutions containing different Hg²⁺ concentrations. Furthermore, the Gin-AgNPs and Gin-AgNPs hydrogels exhibited antibacterial effects against both Gram-negative and Gram-positive bacteria, indicating potential future applications in the detection of Hg²⁺ and in wound healing.

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Gingerol extract-stabilized silver nanoparticles and their applications: colorimetric and machine learning-based sensing of Hg(ii) and antibacterial properties†

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