Issue 33, 2023

Visible-light mediated, oxygen-promoted regioselective cross-dehydrogenative coupling of coumarins and dimethylanilines

Abstract

Herein, we report a regioselective, photocatalytic C3 α-aminoalkylation of coumarins via a cross-dehydrogenative coupling of dimethylanilines and coumarins. Molecular oxygen was utilized as the oxidizing agent in this transformation, which exhibits a wide substrate scope and affords the products in good yields. It was established that 4-amino-substituted coumarin reacts via a different mechanism compared to coumarin derivatives that are unsubstituted at the 4-position.

Graphical abstract: Visible-light mediated, oxygen-promoted regioselective cross-dehydrogenative coupling of coumarins and dimethylanilines

Supplementary files

Article information

Article type
Communication
Submitted
11 Jun 2023
Accepted
26 Jul 2023
First published
04 Aug 2023

Org. Biomol. Chem., 2023,21, 6671-6674

Visible-light mediated, oxygen-promoted regioselective cross-dehydrogenative coupling of coumarins and dimethylanilines

T. Singh, G. C. Upreti, S. Arora, H. Chauhan and A. Singh, Org. Biomol. Chem., 2023, 21, 6671 DOI: 10.1039/D3OB00923H

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