Assembly and optically triggered disassembly of lipid–DNA origami fibers

Sofia Julin; Nadine Best; Eduardo Anaya-Plaza; Eeva Enlund; Veikko Linko; Mauri A. Kostiainen

doi:10.1039/D3CC04677J

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Assembly and optically triggered disassembly of lipid–DNA origami fibers†

Sofia Julin,

^a Nadine Best,

^abc Eduardo Anaya-Plaza,

^a Eeva Enlund,^a Veikko Linko

^ad and Mauri A. Kostiainen

*^ae

Author affiliations

* Corresponding authors

^a Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland
E-mail: mauri.kostiainen@aalto.fi

^b Technische Universität Darmstadt, 64289 Darmstadt, Germany

^c Fraunhofer Institute for Microengineering and Microsystems IMM, 55129 Mainz, Germany

^d Institute of Technology, University of Tartu, 50411 Tartu, Estonia

^e LIBER Center of Excellence, Aalto University, 00076 Aalto, Finland

Abstract

The co-assembly of lipids and other compounds has recently gained increasing interest. Here, we report the formation of stimuli-responsive lipid–DNA origami fibers through the electrostatic co-assembly of cationic lipids and 6-helix bundle (6HB) DNA origami. The photosensitive lipid degrades when exposed to UV-A light, which allows a photoinduced, controlled release of the 6HBs from the fibers. The presented complexation strategy may find uses in developing responsive nanomaterials e.g. for therapeutics.

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Article information

DOI: https://doi.org/10.1039/D3CC04677J
Article type: Communication
Submitted: 20 Sep 2023
Accepted: 08 Nov 2023
First published: 09 Nov 2023
This article is Open Access

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Chem. Commun., 2023,59, 14701-14704

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Assembly and optically triggered disassembly of lipid–DNA origami fibers

S. Julin, N. Best, E. Anaya-Plaza, E. Enlund, V. Linko and M. A. Kostiainen, Chem. Commun., 2023, 59, 14701 DOI: 10.1039/D3CC04677J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Communications

Assembly and optically triggered disassembly of lipid–DNA origami fibers†

Abstract

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Assembly and optically triggered disassembly of lipid–DNA origami fibers

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