Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector

Andrew J. Hall; Amy G. Robertson; Robert W. Baker; Leila R. Hill; Louis M. Rendina

doi:10.1039/D3CC02706F

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Significant cell uptake of Gd(iii)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector†

Andrew J. Hall,

^a Amy G. Robertson,^a Robert W. Baker,

^a Leila R. Hill

^a and Louis M. Rendina

*^ab

Author affiliations

* Corresponding authors

^a School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
E-mail: louis.rendina@sydney.edu.au

^b The University of Sydney Nano Institute, Sydney, NSW 2006, Australia

Abstract

The synthesis, characterisation, and tumour cell uptake of six novel Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes are reported. The propyl-linked Gd(III) complexes can accumulate inside human glioma cells at prodigious levels, approaching 1200%, over the parent triphenylphosphonium salts. DFT and quantum chemical topology analyses support a new type of conformationally-dependent tumour cell targeting vector.

This article is part of the themed collection: Celebrating the scientific accomplishments of RSC Fellows

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Article information

DOI: https://doi.org/10.1039/D3CC02706F
Article type: Communication
Submitted: 06 Jun 2023
Accepted: 26 Sep 2023
First published: 04 Oct 2023

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Chem. Commun., 2023,59, 12511-12514

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Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector

A. J. Hall, A. G. Robertson, R. W. Baker, L. R. Hill and L. M. Rendina, Chem. Commun., 2023, 59, 12511 DOI: 10.1039/D3CC02706F

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Chemical Communications

Significant cell uptake of Gd(iii)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector†

Abstract

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Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector

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