Issue 18, 2023

Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration

Abstract

Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.

Graphical abstract: Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration

Article information

Article type
Review Article
Submitted
02 Apr 2023
Accepted
09 Jul 2023
First published
31 Jul 2023
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2023,11, 6035-6059

Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration

B. Mi, Y. Xiong, K. Zha, F. Cao, W. Zhou, S. Abbaszadeh, L. Ouyang, Y. Liao, W. Hu, G. Dai, Z. Zhao, Q. Feng, M. Shahbazi and G. Liu, Biomater. Sci., 2023, 11, 6035 DOI: 10.1039/D3BM00544E

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