Issue 8, 2023
From the journal:

Biomaterials Science

Structural optimization of BODIPY photosensitizers for enhanced photodynamic antibacterial activities†

Hui Wen,ab   Qihang Wu,ab   Liqian Liu,ab   Yite Li,ab   Tingting Sun ORCID logo *a  and  Zhigang Xie ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China
E-mail: suntt@ciac.ac.cn, xiez@ciac.ac.cn

b University of Science and Technology of China, Hefei 230026, P. R. China

Abstract

Enhancing the interactions between photosensitizers and bacteria is key to developing effective photodynamic antibacterial agents. However, the influence of different structures on the therapeutic effects has not been systematically investigated. Herein, 4 BODIPYs with distinct functional groups, including the phenylboronic acid (PBA) group and pyridine (Py) cations, were designed to explore their photodynamic antibacterial activities. The BODIPY with the PBA group (IBDPPe-PBA) exhibits potent activity against planktonic Staphylococcus aureus (S. aureus) upon illumination, while the BODIPY with Py cations (IBDPPy-Ph) or both the PBA group and Py cations (IBDPPy-PBA) can significantly minimize the growth of both S. aureus and Escherichia coli (E. coli). In particular, IBDPPy-Ph can not only eliminate the mature S. aureus biofilm and E. coli biofilm in vitro, but also promote the healing of the infected wound. Our work provides an alternative for reasonable design of photodynamic antibacterial materials.

Graphical abstract: Structural optimization of BODIPY photosensitizers for enhanced photodynamic antibacterial activities

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Article information

DOI
https://doi.org/10.1039/D3BM00073G
Article type
Paper
Submitted
16 Jan 2023
Accepted
16 Feb 2023
First published
21 Feb 2023
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2023,11, 2870-2876

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Structural optimization of BODIPY photosensitizers for enhanced photodynamic antibacterial activities

H. Wen, Q. Wu, L. Liu, Y. Li, T. Sun and Z. Xie, Biomater. Sci., 2023, 11, 2870 DOI: 10.1039/D3BM00073G

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