Issue 4, 2023
From the journal:

RSC Advances

A rapid construction of 1,3,2-benzodiazaborininones [R–B(aam)] from boronic acids and anthranilamides†

Siwei Liao,‡a   Kai Liu,‡b   Huili Wu,a   Qiulin Kuang,a   Xueyuan Hu,a   Yihao Li,a   Hongxiao Lua  and  Jianyong Yuan ORCID logo *a  

* Corresponding authors

a Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China
E-mail: yuanjianyong@cqmu.edu.cn

b Department of Pharmacy, Chongqing Public Health Medical Center, PR China

Abstract

A simple, efficient and mild methodology for the synthesis of 1,3,2-benzodiazaborininones [R–B(aam)] from boronic acids and anthranilamides on ethyl acetate is described. A series of 1,3,2-benzodiazaborininones were prepared in moderate to excellent yields at room temperature without dehydrating agents, metal catalysts, corrosive acids or other additives. Meanwhile, a multi-gram scale reaction is also performed to ensure the scalability of the reaction, and the product can be conveniently isolated by simple filtration.

Graphical abstract: A rapid construction of 1,3,2-benzodiazaborininones [R–B(aam)] from boronic acids and anthranilamides

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Article information

DOI
https://doi.org/10.1039/D2RA06573H
Article type
Paper
Submitted
18 Oct 2022
Accepted
20 Dec 2022
First published
18 Jan 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 2570-2573

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A rapid construction of 1,3,2-benzodiazaborininones [R–B(aam)] from boronic acids and anthranilamides

S. Liao, K. Liu, H. Wu, Q. Kuang, X. Hu, Y. Li, H. Lu and J. Yuan, RSC Adv., 2023, 13, 2570 DOI: 10.1039/D2RA06573H

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