Issue 33, 2022
From the journal:

RSC Advances

Peptide therapeutics in the management of metastatic cancers

Debopriya Bose,†a   Laboni Roy†a  and  Subhrangsu Chatterjee ORCID logo *a  

* Corresponding authors

a Department of Biophysics Bose Institute, Unified Academic Campus EN 80, Sector V, Bidhan Nagar, Kolkata 700091, WB, India
E-mail: subhrangsu@gmail.com

Abstract

Cancer remains a leading health concern threatening lives of millions of patients worldwide. Peptide-based drugs provide a valuable alternative to chemotherapeutics as they are highly specific, cheap, less toxic and easier to synthesize compared to other drugs. In this review, we have discussed various modes in which peptides are being used to curb cancer. Our review highlights specially the various anti-metastatic peptide-based agents developed by targeting a plethora of cellular factors. Herein we have given a special focus on integrins as targets for peptide drugs, as these molecules play key roles in metastatic progression. The review also discusses use of peptides as anti-cancer vaccines and their efficiency as drug-delivery tools. We hope this work will give the reader a clear idea of the mechanisms of peptide-based anti-cancer therapeutics and encourage the development of superior drugs in the future.

Graphical abstract: Peptide therapeutics in the management of metastatic cancers

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Article information

DOI
https://doi.org/10.1039/D2RA02062A
Article type
Review Article
Submitted
30 Mar 2022
Accepted
26 Jun 2022
First published
02 Aug 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 21353-21373

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Peptide therapeutics in the management of metastatic cancers

D. Bose, L. Roy and S. Chatterjee, RSC Adv., 2022, 12, 21353 DOI: 10.1039/D2RA02062A

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