Issue 19, 2022

Transition-metal-catalyst-free reaction of amides and acetonitriles: synthesis of β-ketonitriles

Abstract

Amides react with acetonitrile in the presence of LiHMDS to produce the corresponding β-ketonitriles in good yields. Both activated and unactivated amides show good activity at room temperature in the absence of transition metal catalysts. A wide variety of functional groups was tolerated, including both electron-donating and electron-withdrawing substituents, and the desired β-ketonitriles were obtained in good-to-excellent yields.

Graphical abstract: Transition-metal-catalyst-free reaction of amides and acetonitriles: synthesis of β-ketonitriles

Supplementary files

Article information

Article type
Research Article
Submitted
01 Jun 2022
Accepted
12 Aug 2022
First published
15 Aug 2022

Org. Chem. Front., 2022,9, 5178-5184

Transition-metal-catalyst-free reaction of amides and acetonitriles: synthesis of β-ketonitriles

M. S. Park and S. Lee, Org. Chem. Front., 2022, 9, 5178 DOI: 10.1039/D2QO00884J

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