SCHEDULED MAINTENANCE
Highly selective electrophilic B(9)-amination of o-carborane driven by HOTf and HFIP†
Yan-Na
Ma 
*b
and
Xuenian
Chen
*ab
*b
and
Xuenian
Chen
*ab
Abstract
Despite the great importance of nitrogen-containing carboranes in organic and pharmaceutical syntheses, current methods to generate them are very limited and usually rely on the use of expensive transition metals. Herein, an efficient B(9) electrophilic amination of o-carboranes with azodicarboxylates, promoted by a Brønsted acid and HFIP, has been developed. The reaction proceeded smoothly under metal-free conditions and could be easily scaled up, giving B(9)-aminated o-carboranes in moderate to good yields and excellent selectivity under air.
- This article is part of the themed collection: FOCUS: Frontiers in Boron Chemistry
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