Issue 18, 2022

Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes

Abstract

An enantioselective metal-free hydrogenation of TIPS-protected oximes has been successfully realized for the first time by using chiral borane catalysts derived from chiral dienes and Piers’ borane. A variety of hydroxylamine derivatives were afforded in 84–99% yields with 33–68% ees.

Graphical abstract: Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes

Supplementary files

Article information

Article type
Communication
Submitted
30 Mar 2022
Accepted
12 Apr 2022
First published
12 Apr 2022

Org. Biomol. Chem., 2022,20, 3708-3711

Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes

K. Yu, X. Feng and H. Du, Org. Biomol. Chem., 2022, 20, 3708 DOI: 10.1039/D2OB00602B

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