Issue 20, 2022
From the journal:

Nanoscale Advances

Revealing the structure and organization of intercellular tunneling nanotubes (TNTs) by STORM imaging†

Lilin Huang,‡a   Jiao Zhang,‡a   Zekai Wu,a   Liangliang Zhou,a   Bin Yu,a   Yingying Jing,*a   Danying Lin ORCID logo *a  and  Junle Qu ORCID logo a  

* Corresponding authors

a Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
E-mail: dylin@szu.edu.cn, yyjing@szu.edu.cn

Abstract

Tunneling nanotubes (TNTs) are nanoscale, actin-rich, transient intercellular tubes for cell-to-cell communication, which transport various cargoes between distant cells. The structural complexity and spatial organization of the involved components of TNTs remain unknown. In this work, the STORM super-resolution imaging technique was applied to elucidate the structural organization of microfilaments and microtubules in intercellular TNTs at the nanometer scale. Our results reveal different distributions of microfilaments and intertwined structures of microtubules in TNTs, which promote the knowledge of TNT communications.

Graphical abstract: Revealing the structure and organization of intercellular tunneling nanotubes (TNTs) by STORM imaging

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Article information

DOI
https://doi.org/10.1039/D2NA00415A
Article type
Communication
Submitted
28 Jun 2022
Accepted
08 Sep 2022
First published
08 Sep 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 4258-4262

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Revealing the structure and organization of intercellular tunneling nanotubes (TNTs) by STORM imaging

L. Huang, J. Zhang, Z. Wu, L. Zhou, B. Yu, Y. Jing, D. Lin and J. Qu, Nanoscale Adv., 2022, 4, 4258 DOI: 10.1039/D2NA00415A

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