Issue 6, 2023
From the journal:

Dalton Transactions

Ferrocene-triazole conjugates: do we know why they are biologically active?

Mariola Koszytkowska-Stawińska*a  and  Włodzimierz Buchowicz ORCID logo *a  

* Corresponding authors

a Faculty of Chemistry, Chair of Organic Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
E-mail: wlodzimierz.buchowicz@pw.edu.pl

Abstract

The bioorganometallic chemistry of ferrocene has been gaining significance in recent years. This review presents ferrocene-triazole conjugates displaying significant biological properties. The conjugates have been synthesized via azide–alkyne cycloaddition reactions. The data are summarized according to the type of activity (anticancer, antibacterial and/or antifungal, antiprotozoal, and other effects). The results of studies concerning the understanding of the role of the ferrocene core in their biological activity are highlighted. While generally the mode of action of these organometallic species remains unclear, the importance of redox properties of ferrocene has been postulated in several cases.

Graphical abstract: Ferrocene-triazole conjugates: do we know why they are biologically active?

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Article information

DOI
https://doi.org/10.1039/D2DT03161B
Article type
Perspective
Submitted
29 Sep 2022
Accepted
21 Dec 2022
First published
21 Dec 2022
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2023,52, 1501-1517

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Ferrocene-triazole conjugates: do we know why they are biologically active?

M. Koszytkowska-Stawińska and W. Buchowicz, Dalton Trans., 2023, 52, 1501 DOI: 10.1039/D2DT03161B

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