Similar to graphene and fullerene, metal-doping has been considered to be an effective approach to the construction of highly stable boron clusters. In this work, a series of actinide metal-doped boron clusters AnB₃₆ (An = Pa, Np, Pu, Am, Cm, Bk, and Cf) have been explored using extensive first-principles calculations. We found that the quasi-planar structure of B₃₆ transforms to an endohedral borospherene An@B₃₆ after actinide metal doping. Actinoborospherenes exhibit C_2h symmetry with Pa, Np, and Pu dopants and for Am, Cm, Bk and Cf dopants with larger atomic radii, the symmetry of An@B₃₆ is reduced to C_i. Bonding property analyses such as bond order, molecular orbital (MO) and quantum theory of atoms in molecules (QTAIM) analysis show that the covalency of the An–B bonds in C_2h An@B₃₆ (An = Pa, Np, and Pu) is higher than that in C_i An@B₃₆ (An = Am, Cm, Bk, and Cf). These endohedral borospherenes are robust according to thermodynamic and dynamic analyses. As expected, the C_i An@B₃₆ clusters are less stable compared to C_2h An@B₃₆, which is consistent with the stronger covalent bonds of the latter. These results indicate that the existence of the actinide–boron bonding is essential for the high stability of the An@B₃₆ clusters, confirming that the fullerene-like boron cages can be stabilized by actinide encapsulation. This work is expected to provide potential routes for the construction of robust borospherenes.