Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

Han Gao; Lin Guo; Yining Zhu; Chao Yang; Wujiong Xia

doi:10.1039/D2CC06507J

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Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts†

Han Gao,

^a Lin Guo,^a Yining Zhu,^a Chao Yang

*^a and Wujiong Xia

*^ab

Author affiliations

* Corresponding authors

^a State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, China
E-mail: xyyang@hit.edu.cn, xiawj@hit.edu.cn

^b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, China

Abstract

A direct dehydrogenative amidation reaction of aldehydes and amines under a visible light mediated ligand-to-metal charge transfer (LMCT) process was described. In this protocol, aldehyde substrates were activated by photoinduced hydrogen atom abstraction (HAA), generating acyl chloride intermediates followed by nucleophilic addition of amines. The synthetic method furnishes good functional group tolerance and broad substrate scope toward both aliphatic and aromatic components.

This article is part of the themed collection: Photofunctional Materials and Transformations

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Article information

DOI: https://doi.org/10.1039/D2CC06507J
Article type: Communication
Submitted: 30 Nov 2022
Accepted: 07 Feb 2023
First published: 07 Feb 2023

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Chem. Commun., 2023,59, 2771-2774

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Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

H. Gao, L. Guo, Y. Zhu, C. Yang and W. Xia, Chem. Commun., 2023, 59, 2771 DOI: 10.1039/D2CC06507J

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Chemical Communications

Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts†

Abstract

Supplementary files

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Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts

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