Issue 94, 2022
From the journal:

Chemical Communications

A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing†

Yanmei Zhou, ORCID logo a   Zhaoge Li,a   Tian Wu,a   Juan Ning,a   Guizhen Hua  and  Yamin Nie ORCID logo *a  

* Corresponding authors

a Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China
E-mail: ymnie@henu.edu.cn

Abstract

A programmed DNA–Au nanomachine has been constructed to achieve in situ imaging of transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger gene silencing therapy. The results of MCF-7 cell-specific imaging and apoptosis experiments demonstrate that the nanomachine provides a valuable nanotheranostic platform for accurate multi-site imaging and intracellular gene silencing.

Graphical abstract: A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing

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Article information

DOI
https://doi.org/10.1039/D2CC05017J
Article type
Communication
Submitted
12 Sep 2022
Accepted
01 Nov 2022
First published
01 Nov 2022

Chem. Commun., 2022,58, 13107-13110

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A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing

Y. Zhou, Z. Li, T. Wu, J. Ning, G. Hu and Y. Nie, Chem. Commun., 2022, 58, 13107 DOI: 10.1039/D2CC05017J

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