Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

Kiyan Musaie; Samin Abbaszadeh; Vahideh Nosrati-Siahmazgi; Mostafa Qahremani; Shige Wang; Mohammad Reza Eskandari; Seyyed Vahid Niknezhad; Fakhri Haghi; Yulin Li; Bo Xiao; Mohammad-Ali Shahbazi

doi:10.1039/D2BM01965E

Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair†

Kiyan Musaie,^a Samin Abbaszadeh,^b Vahideh Nosrati-Siahmazgi,^a Mostafa Qahremani,^a Shige Wang,^c Mohammad Reza Eskandari,^d Seyyed Vahid Niknezhad,^e Fakhri Haghi,^f Yulin Li,

^g Bo Xiao

*^h and Mohammad-Ali Shahbazi

*^aij

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Science, 45139-56184 Zanjan, Iran

^b Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111 Zanjan, Iran

^c School of Materials and Chemistry, the University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, P.R. China

^d Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Science, 45139-56184 Zanjan, Iran

^e Program in Craniofacial Biology, Department of Cell and Tissue Biology, University of California, San Francisco, CA 1, USA

^f Department of Microbiology and Immunology, Faculty of Medical Sciences, Zanjan University of Medical Sciences, 45139-56111 Zanjan, Iran

^g Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

^h State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400715 China
E-mail: bxiao@swu.edu.cn

ⁱ Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands
E-mail: m.a.shahbazi@umcg.nl

^j W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

Abstract

Photothermal therapy (PTT) is a promising approach for treating cancer. However, it suffers from the formation of local lesions and subsequent bacterial infection in the damaged area. To overcome these challenges, the strategy of mild PTT following the high-temperature ablation of tumors is studied to achieve combined tumor suppression, wound healing, and bacterial eradication using a hydrogel. Herein, Bi₂S₃ nanorods (NRs) are employed as a photothermal agent and coated with hyaluronic acid to obtain BiH NRs with high colloidal stability. These NRs and allantoin are loaded into an injectable Fe³⁺-coordinated hydrogel composed of sodium alginate (Alg) and Farsi gum (FG), which is extracted from Amygdalus scoparia Spach. The hydrogel can be used for localized cancer therapy by high-temperature PTT, followed by wound repair through the combination of mild hyperthermia and allantoin-mediated induction of cell proliferation. In addition, an outstanding blood clotting effect is observed due to the water-absorbing ability and negative charge of FG and Alg as well as the porous structure of hydrogels. The hydrogels also eradicate infection owing to the local heat generation and intrinsic antimicrobial activity of the NRs. Lastly, in vivo studies reveal an efficient photothermal-based tumor eradication and accelerated wound healing by the hydrogel.

Biomaterials Science

Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

Social activity

Search articles by author

Spotlight

Advertisements