Issue 10, 2022

Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers

Abstract

Radiation therapy is a powerful approach for cancer treatment due to its low invasiveness. The development of radiation sensitizers is of great importance as they assist in providing radiation therapy at a low dose. In this study, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-modified gold nanocomposites of different shapes were created using the grafting-to approach to serve as a novel radiation sensitizer with high cellular uptake. The effect of the shape of the nanocomposite on cellular uptake by the breast cancer cell line MCF-7 was also investigated. The PMPC-modified gold nanostars showed the highest cellular uptake compared to the other gold nanocomposites (spheres and rods), whereas cell cytotoxicity was negligible among all candidates. Furthermore, the therapeutic effect of radiation of PMPC-modified nanostars was the highest among all the gold nanocomposites. These results clearly indicate that the shape of the gold nanocomposite is an important parameter for cellular uptake and radiation sensitizing effects in breast cancer cells.

Graphical abstract: Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers

Supplementary files

Article information

Article type
Paper
Submitted
04 Feb 2022
Accepted
23 Mar 2022
First published
14 Apr 2022

Biomater. Sci., 2022,10, 2665-2672

Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers

A. Yoshida, Y. Kitayama, N. Hayakawa, Y. Mizukawa, Y. Nishimura, E. Takano, H. Sunayama and T. Takeuchi, Biomater. Sci., 2022, 10, 2665 DOI: 10.1039/D2BM00174H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements