Amorphous and crystalline cerium(IV) phosphates: biocompatible ROS-scavenging sunscreens

T. O. Kozlova; A. L. Popov; I. V. Kolesnik; D. D. Kolmanovich; A. E. Baranchikov; A. B. Shcherbakov; V. K. Ivanov

doi:10.1039/D1TB02604F

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens†

T. O. Kozlova,

^a A. L. Popov,

^b I. V. Kolesnik,^c D. D. Kolmanovich,^b A. E. Baranchikov,

^a A. B. Shcherbakov

^d and V. K. Ivanov

*^a

Author affiliations

* Corresponding authors

^a Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia
E-mail: van@igic.ras.ru

^b Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino, Moscow region 142290, Russia

^c Lomonosov Moscow State University, Materials Science Department, Moscow 119991, Russia

^d Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine

Abstract

This paper reports on a comprehensive study of the UV-shielding properties (namely, the sun protection factor and the factor of protection against UV-A radiation) and cytotoxicity (including photocytotoxicity) of amorphous and crystalline cerium(IV) phosphates. It has been shown that cerium(IV) phosphate NH₄Ce₂(PO₄)₃ is characterised by UV-shielding properties that are comparable to those of nanocrystalline TiO₂ and CeO₂. Moreover, cerium(IV) phosphates did not show toxicity towards cell cultures of NCTC L929 line mouse fibroblasts and human mesenchymal stem cells, in a wide range of concentrations, and even enhanced the proliferative activity of the latter. In a model study of the photoprotective properties of cerium(IV) phosphates on human mesenchymal stem cells, the pronounced protective effect of NH₄Ce₂(PO₄)₃ was observed, which was comparable to the shielding action of nanocrystalline CeO₂. The results have shown that tetravalent cerium phosphates can be considered as promising UV-filters for sunscreen applications.

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DOI: https://doi.org/10.1039/D1TB02604F
Article type: Paper
Submitted: 25 Nov 2021
Accepted: 26 Jan 2022
First published: 27 Jan 2022

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J. Mater. Chem. B, 2022,10, 1775-1785

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Amorphous and crystalline cerium(IV) phosphates: biocompatible ROS-scavenging sunscreens

T. O. Kozlova, A. L. Popov, I. V. Kolesnik, D. D. Kolmanovich, A. E. Baranchikov, A. B. Shcherbakov and V. K. Ivanov, J. Mater. Chem. B, 2022, 10, 1775 DOI: 10.1039/D1TB02604F

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Journal of Materials Chemistry B

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens†

Abstract

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Amorphous and crystalline cerium(IV) phosphates: biocompatible ROS-scavenging sunscreens

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