Issue 40, 2021, Issue in Progress
From the journal:

RSC Advances

Protection of lead-induced cytotoxicity using paramagnetic nickel–insulin quantum clusters†

Deepinder Sharda,a   Komal Attri,ab   Pawandeep Kaura  and  Diptiman Choudhury ORCID logo *ab  

* Corresponding authors

a School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, Punjab, India
E-mail: diptiman@thapar.edu
Tel: +91-8196949843

b Thapar Institute of Engineering and Technology-Virginia Tech (USA) Center of Excellence in Emerging Materials, Thapar Institute of Engineering and Technology, Patiala, Punjab-147004, India

Abstract

Pb-toxicity is associated with inflammation which leads to delay in wound healing. Pb2+ utilizes calcium ion channels to enter the cell. Therefore, to achieve effective healing in a Pb-poisoned system, capturing Pb2+ from the circulatory system would be an effective approach without hampering the activity of the calcium ion channel. In this work insulin–nickel fluorescent quantum clusters (INiQCs) have been synthesized and used for the specific detection of Pb2+ ions in vitro and in cell-free systems. INiQCs (0.09 μM) can detect Pb2+ concentrations as low as 10 pM effectively in a cell-free system using the fluorescence turn-off method. In vitro INiQCs (0.45 μM) can detect Pb2+ concentrations as low as 1 μM. INiQCs also promote wound healing which can easily be monitored using the bright fluorescence of INiQCs. INiQCs also help to overcome the wound recovery inhibitory effect of Pb2+ in vitro using lead nitrate. This work helps to generate effective biocompatible therapeutics for wound recovery in Pb2+ poisoned individuals.

Graphical abstract: Protection of lead-induced cytotoxicity using paramagnetic nickel–insulin quantum clusters

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Article information

DOI
https://doi.org/10.1039/D1RA03597E
Article type
Paper
Submitted
08 May 2021
Accepted
29 Jun 2021
First published
14 Jul 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 24656-24668

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Protection of lead-induced cytotoxicity using paramagnetic nickel–insulin quantum clusters

D. Sharda, K. Attri, P. Kaur and D. Choudhury, RSC Adv., 2021, 11, 24656 DOI: 10.1039/D1RA03597E

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