Issue 8, 2021, Issue in Progress

Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates

Abstract

A transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C–Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility.

Graphical abstract: Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates

Supplementary files

Article information

Article type
Paper
Submitted
04 Jan 2021
Accepted
15 Jan 2021
First published
22 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 4593-4597

Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates

W. Xing, D. Liu and M. Fu, RSC Adv., 2021, 11, 4593 DOI: 10.1039/D1RA00063B

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