Sarcanolides C–E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra

Long-Gao Xiao; Ping Li; Huan Yan; Wei Ni; Li He; Hai-Yang Liu

doi:10.1039/D1OB02417E

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Sarcanolides C–E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra†

Long-Gao Xiao,

‡^ab Ping Li,‡^a Huan Yan,‡^a Wei Ni,^a Li He*^c and Hai-Yang Liu

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
E-mail: haiyangliu@mail.kib.ac.cn

^b University of Chinese Academy of Sciences, Beijing, China

^c Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China
E-mail: drheli2662@126.com

Abstract

Three new lindenane-type sesquiterpenoid dimers, sarcanolides C–E (1–3), were isolated from the roots of Sarcandra glabra. Sarcanolide C (1) possesses a unique decacyclic scaffold with an unusual orthoformate unit. The structures of 1–3 were determined through extensive spectroscopic analysis, while their absolute configurations were determined by comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1–3 were evaluated for their inhibitory activity against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages. All the isolates displayed a moderate inhibitory effect against NO production with IC₅₀ values in the range of 13.4–17.2 μM, comparable to that of the positive control L-NMMA.

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Article information

DOI: https://doi.org/10.1039/D1OB02417E
Article type: Paper
Submitted: 12 Dec 2021
Accepted: 18 Jan 2022
First published: 20 Jan 2022

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Org. Biomol. Chem., 2022,20, 1320-1326

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Sarcanolides C–E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra

L. Xiao, P. Li, H. Yan, W. Ni, L. He and H. Liu, Org. Biomol. Chem., 2022, 20, 1320 DOI: 10.1039/D1OB02417E

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Organic & Biomolecular Chemistry

Sarcanolides C–E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra†

Abstract

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Sarcanolides C–E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra

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