SCHEDULED MAINTENANCE
Electrochemical sulfonylation of imidazoheterocycles under batch and continuous flow conditions†
Maël
Penhoat 
a
and
Laëtitia
Chausset-Boissarie
*a
a
and
Laëtitia
Chausset-Boissarie
*a
Abstract
An efficient and versatile protocol for the C–H sulfonylation of imidazoheterocycles via electrochemical activation was established under batch and flow conditions. The selective C–H bond functionalization proceeded under catalyst- and oxidant-free conditions and tolerated a wide range of functional groups. Various sodium sulfinates as well as imidazo[1,2-a]-pyridines, -pyrimidine, -quinolines, and -isoquinolines, imidazo[1,2-b]pyridazine, imidazo[2,1-b]thiazoles and benzo[d]imidazo[1,2-b]thiazoles reacted successfully. Interestingly, significant acceleration and higher yields were obtained under microfluidic conditions.
- This article is part of the themed collection: Synthetic methodology in OBC
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